Monoacylglycerol lipase (MAGL) as a promising therapeutic target
A Gil-Ordóñez, M Martín-Fontecha… - Biochemical …, 2018 - Elsevier
Monoacylglycerol lipase (MAGL) has been characterized as the main enzyme responsible
for the inactivation of the most abundant brain endocannabinoid, 2-arachidonoylglycerol (2 …
for the inactivation of the most abundant brain endocannabinoid, 2-arachidonoylglycerol (2 …
Positron emission tomography imaging of the endocannabinoid system: opportunities and challenges in radiotracer development
The endocannabinoid system (ECS) is involved in a wide range of biological functions and
comprises cannabinoid receptors and enzymes responsible for endocannabinoid synthesis …
comprises cannabinoid receptors and enzymes responsible for endocannabinoid synthesis …
Identification of ABX-1431, a selective inhibitor of monoacylglycerol lipase and clinical candidate for treatment of neurological disorders
JS Cisar, OD Weber, JR Clapper… - Journal of medicinal …, 2018 - ACS Publications
The serine hydrolase monoacylglycerol lipase (MGLL) converts the endogenous
cannabinoid receptor agonist 2-arachidonoylglycerol (2-AG) and other monoacylglycerols …
cannabinoid receptor agonist 2-arachidonoylglycerol (2-AG) and other monoacylglycerols …
2-Arachidonoylglycerol modulation of anxiety and stress adaptation: from grass roots to novel therapeutics
Over the past decade there has been a surge of interest in the development of
endocannabinoid-based therapeutic approaches for the treatment of diverse …
endocannabinoid-based therapeutic approaches for the treatment of diverse …
Development of high brain-penetrant and reversible monoacylglycerol lipase PET tracers for neuroimaging
Monoacylglycerol lipase (MAGL) is one of the key enzymes in the endocannabinoid system.
Inhibition of MAGL has been proposed as an attractive approach for the treatment of various …
Inhibition of MAGL has been proposed as an attractive approach for the treatment of various …
Design, synthesis, and evaluation of reversible and irreversible monoacylglycerol lipase positron emission tomography (PET) tracers using a “tail switching” strategy …
Monoacylglycerol lipase (MAGL) is a serine hydrolase that degrades 2-arachidonoylglycerol
(2-AG) in the endocannabinoid system (eCB). Selective inhibition of MAGL has emerged as …
(2-AG) in the endocannabinoid system (eCB). Selective inhibition of MAGL has emerged as …
In Vitro and in Vivo Evaluation of 11C-Labeled Azetidinecarboxylates for Imaging Monoacylglycerol Lipase by PET Imaging Studies
R Cheng, W Mori, L Ma, M Alhouayek… - Journal of medicinal …, 2018 - ACS Publications
Monoacylglycerol lipase (MAGL) is the principle enzyme for metabolizing endogenous
cannabinoid ligand 2-arachidonoyglycerol (2-AG). Blockade of MAGL increases 2-AG …
cannabinoid ligand 2-arachidonoyglycerol (2-AG). Blockade of MAGL increases 2-AG …
Identification and development of an irreversible monoacylglycerol lipase (MAGL) positron emission tomography (PET) radioligand with high specificity
L Zhang, CR Butler, KP Maresca… - Journal of Medicinal …, 2019 - ACS Publications
Monoacylglycerol lipase (MAGL), a serine hydrolase extensively expressed throughout the
brain, serves as a key gatekeeper regulating the tone of endocannabinoid signaling …
brain, serves as a key gatekeeper regulating the tone of endocannabinoid signaling …
Design, Synthesis, and Evaluation of 18F-Labeled Monoacylglycerol Lipase Inhibitors as Novel Positron Emission Tomography Probes
Z Chen, W Mori, H Fu, MA Schafroth… - Journal of medicinal …, 2019 - ACS Publications
Dysfunction of monoacylglycerol lipase (MAGL) is associated with several
psychopathological disorders, including drug addiction and neurodegenerative diseases …
psychopathological disorders, including drug addiction and neurodegenerative diseases …
Design, Synthesis, and Evaluation of (4R)-1-{3-[2-(18F)Fluoro-4-methylpyridin-3-yl]phenyl}-4-[4-(1,3-thiazol-2-ylcarbonyl)piperazin-1-yl]pyrrolidin-2-one ([18F]T-401 …
Y Hattori, K Aoyama, J Maeda, N Arimura… - Journal of medicinal …, 2019 - ACS Publications
Monoacylglycerol lipase (MAGL) is a cytosolic serine hydrolase involved in
endocannabinoid and inflammatory signaling. Positron-emission tomography (PET) imaging …
endocannabinoid and inflammatory signaling. Positron-emission tomography (PET) imaging …