Immuno-positron emission tomography (immunoPET) is a paradigm-shifting molecular
imaging modality combining the superior targeting specificity of monoclonal antibody (mAb) …

Fluorescent small molecules are powerful tools for visualizing biological events, embodying
an essential facet of chemical biology. Since the discovery of the first organic fluorophore …

Genetically encoded voltage indicators (GEVIs) enable monitoring of neuronal activity at
high spatial and temporal resolution. However, the utility of existing GEVIs has been limited …

Specific labeling of biomolecules with bright fluorophores is the keystone of fluorescence
microscopy. Genetically encoded self-labeling tag proteins can be coupled to synthetic dyes …

The covalent immobilisation of enzymes generally involves the use of highly reactive
crosslinkers, such as glutaraldehyde, to couple enzyme molecules to each other or to …

Functional imaging using fluorescent indicators has revolutionized biology, but additional
sensor scaffolds are needed to access properties such as bright, far-red emission. Here, we …

Abstract Three-dimensional (3D) reconstruction of living brain tissue down to an individual
synapse level would create opportunities for decoding the dynamics and structure–function …

Rhodamine dyes are excellent scaffolds for developing a broad range of fluorescent probes.
A key property of rhodamines is their equilibrium between a colorless lactone and …

Direct visualization of genomic loci in the 3D nucleus is important for understanding the
spatial organization of the genome and its association with gene expression. Various DNA …

Exploration of protein function and interaction is critical for discovering links among
genomics, proteomics, and disease state; yet, the immense complexity of proteomics found …