A rate-limiting step in the prevention and early intervention of depressive disorders in young
people is our insufficient understanding of causal mechanisms. One plausible …

Objective To compare the efficacy and discontinuation of augmentation agents in adult
patients with treatment-resistant depression (TRD). We conducted a systematic review and …

Menopause is an inevitable developmental event that women encounter at an age of 42–54
years. The drop of estrogen levels that accompanies cessation of menstruation is associated …

Major mood syndromes are among the most common and disabling mental disorders.
However, a lack of clear delineation of their underlying pathophysiological mechanisms is a …

Introduction Bipolar disorder (BD) is a chronic mental illness impacting 1–2% of the
population worldwide and causing high rates of functional impairment. Patients with BD …

Several drugs previously tested in clinical trials and approved for different indications have
been repurposed for bipolar disorder. We carried out a systematic meta-review of meta …

Objective: The aims of this review were to describe the relationship between obstructive
sleep apnea (OSA) and psychiatric disorders and provide an overview of how to …

Introduction Despite advances in the treatment of bipolar disorder (BD), most patients do not
achieve complete inter-episode recovery and functional disability is common. During …

Background Cariprazine has been approved by the Food and Drug Administration for
treating bipolar depression and as an adjunctive treatment for Major Depressive Disorder …

Objectives Clinicians are often hesitant to prescribe psychostimulants in bipolar disorder
(BD) due to concerns of inducing (hypo) mania, despite limited published evidence on …