[HTML][HTML] Resolution of structural variation in diverse mouse genomes reveals chromatin remodeling due to transposable elements

A Ferraj, PA Audano, P Balachandran, A Czechanski… - Cell Genomics, 2023 - cell.com
Diverse inbred mouse strains are important biomedical research models, yet genome
characterization of many strains is fundamentally lacking in comparison with humans. In …

Utilizing preclinical models of genetic diversity to improve translation of phytochemical activities from rodents to humans and inform personalized nutrition

L Iglesias-Carres, AP Neilson - Food & Function, 2021 - pubs.rsc.org
Mouse models are an essential tool in different areas of research, including nutrition and
phytochemical research. Traditional inbred mouse models have allowed the discovery of …

Stability of quercetin in DMEM and cell culture with A549 cells

H Cao, P Högger, MA Prieto, J Simal‐Gandara, J Xiao - eFood, 2022 - Wiley Online Library
Quercetin is evidently unstable in Dulbecco's modified Eagle's medium (DMEM) at 37° C.
However, the underlying mechanism of this instability is not clear yet. The stability and new …

Water extract of Ferula lehmanni Boiss. prevents high-fat diet-induced overweight and liver injury by modulating the intestinal microbiota in mice

Y Ye, L Shi, P Wang, M Yang, P Zhan, H Tian, J Liu - Food & function, 2022 - pubs.rsc.org
Obesity, often accompanied by hepatic steatosis, has been associated with an increased
risk of health complications such as fatty liver disease and certain cancers. Ferula lehmannii …

[HTML][HTML] Dexamethasone-induced muscle atrophy and bone loss in six genetically diverse collaborative cross founder strains demonstrates phenotypic variability by …

BN Nguyen, S Hong, S Choi, CG Lee, GH Yoo… - Journal of Ginseng …, 2024 - Elsevier
Background Osteosarcopenia is a common condition characterized by the loss of both bone
and muscle mass, which can lead to an increased risk of fractures and disability in older …

Microbial metabolites of flavanols in urine are associated with enhanced anti-proliferative activity in bladder cancer cells in vitro

LE Griffin, SE Kohrt, A Rathore, CD Kay… - Nutrition and …, 2022 - Taylor & Francis
Flavanols are metabolized by the gut microbiota to bioavailable metabolites, and the
absorbed fraction is excreted primarily via urine. Uroepithelial cells are thus a potential site …

Effects of Green Apple (Golden Delicious) and Its Three Major Flavonols Consumption on Obesity, Lipids, and Oxidative Stress in Obese Rats

I Selek Aksoy, S Otles - Molecules, 2022 - mdpi.com
Obesity is becoming increasingly common all over the world and global strategies are
accordingly being developed to prevent it. In order to support the strategies, the effects of …

Cocoa extract exerts sex-specific anti-diabetic effects in an aggressive type-2 diabetes model: A pilot study

KC Racine, L Iglesias-Carres, JA Herring… - Biochemical and …, 2022 - Elsevier
Abstract Type 2 diabetes (T2D) is characterized by hyperglycemia and insulin resistance.
Cocoa may slow T2D development and progression. This study employed male and female …

Journal of Nutritional Biochemistry Special Issue: Polyphenols, obesity, and cardiometabolic health

RS Bruno, AP Neilson, JD Lambert… - The Journal of …, 2021 - Elsevier
The first published research relating to polyphenols potentially occurred in the early 1920s
(Fig. 1). Research in this area remained relatively sparse throughout most of the 20th …

[图书][B] Protective Effects of Cocoa Flavanols Against Obesity and Type 2 Diabetes Are Influenced by Biological Sex and Host Gut Microbiome Composition

KC Racine - 2022 - search.proquest.com
Cocoa (Theobroma cacao) is a concentrated source of flavanols, which may provide
beneficial health activities. Flavanols can be classified by their degree of polymerization …