Reactive oxygen and nitrogen species (RONS) are generated through various endogenous
and exogenous processes; however, they are neutralized by enzymatic and non-enzymatic …

Accumulating evidence shows that oxidative stress is involved in a wide variety of human
diseases: rheumatoid arthritis, Alzheimer's disease, Parkinson's disease, cancers, etc. Here …

DNA molecules in mitochondria, just like those in the nucleus of eukaryotic cells, are
constantly damaged by noxious agents. Eukaryotic cells have developed efficient …

Cells in tissues and organs are continuously subjected to oxidative stress and free radicals
on a daily basis. This free radical attack has exogenous or endogenous (intracellular) origin …

Aging has been associated with damage accumulation in the genome and with increased
cancer incidence. Reactive oxygen species (ROS) are produced from endogenous sources …

Germline mutations are the principal cause of heritable disease and the ultimate source of
evolutionary change. Similarly, somatic mutations are the primary cause of cancer and may …

The DNA damage response and repair (DDR/R) network, a sum of hierarchically structured
signaling pathways that recognize and repair DNA damage, and the immune response to …

High-risk types of human papillomavirus (HPV) are the causative agents of virtually all cases
of cervical cancer and a significant proportion of other anogenital cancers, as well as both …

Glioblastoma multiforme (GBM) is a highly aggressive neoplasia, prognosis remains dismal,
and current therapy is mostly palliative. There are no known risk factors associated with …

Viruses are the causative agents of 10%–15% of human cancers worldwide. The most
common outcome for virus-induced reprogramming is genomic instability, including …