Systemic and local delivery of mesenchymal stem cells for heart renovation: Challenges and innovations

Z Liu, R Mikrani, HM Zubair, A Taleb, M Naveed… - European journal of …, 2020 - Elsevier
In the beginning stage of heart disease, the blockage of blood flow frequently occurs due to
the persistent damage and even death of myocardium. Cicatricial tissue developed after the …

Therapeutic advances in cardiac targeted drug delivery: from theory to practice

C Li, M Naveed, K Dar, Z Liu, MMFA Baig… - Journal of Drug …, 2021 - Taylor & Francis
The most commonly used administration methods in clinics and life are oral administration,
intravenous injection, and other systemic administration methods. Targeted administration …

Intrapericardial Administration to Achieve Localized and Targeted Treatment for Cardiac Disease

Y Xu, Y Chen, JJ Tan, JP Ooi, Z Guo - Journal of Cardiovascular …, 2024 - Springer
Intrapericardial administration has been proposed as an alternative delivery route of
pharmacological agents via the bilaminar sac of pericardium surrounding the heart. To date …

Access routes, devices and guidance methods for intrapericardial delivery in cardiac conditions

HMK Ho, DQM Craig, RM Day - Trends in cardiovascular medicine, 2022 - Elsevier
Drug deposition into the intrapericardial space is favourable for achieving localised effects
and targeted cardiac delivery owing to its proximity to the myocardium as well as facilitating …

[Retracted] Effect of Stellate Ganglion Block Combined with Lidocaine at Different Concentrations for Preemptive Analgesia on Postoperative Pain Relief and Adverse …

Z Wang, J Yu, T Niu, Z Dong… - … and Mathematical Methods …, 2022 - Wiley Online Library
Objective. To explore the effect of stellate ganglion block (SGB) combined with lidocaine at
different concentrations for preemptive analgesia on postoperative pain relief and adverse …

Pharmacokinetic advantage of ASD device promote drug absorption through the epicardium

R Mikrani, C Li, M Naveed, C Li, MMFA Baig… - Pharmaceutical …, 2020 - Springer
Purpose Due to low therapeutic efficacy and severe adverse reaction of systemic
administration for coronary heart disease (CHD) therapy, we designed a novel local target …

[PDF][PDF] 心血管外介入治疗装置的研究进展

汪美玲, 周晓辉 - 中国医疗设备, 2023 - cs.china-cmd.org
外介入治疗装置具备与血液非接触的特点, 从根本上避免了血液感染, 血液生物相容性等问题,
在治疗心血管疾病方面有重要的研究意义. 本文根据外介入治疗装置的功能特点进行归纳分类 …

Myocardial Tissue Repair and Regeneration

K Wang, S Wang, Y Miao, Y Lu, H Zheng… - … Biomaterials for Tissue …, 2023 - Springer
Heart failure caused by myocardial infarction (MI) remains a major threat to human health.
After MI, a series of pathological events take place, including apoptosis of cardiac cells …

An epicardial delivery of nitroglycerine by active hydraulic ventricular support drug delivery system improves cardiac function in a rat model

X Li, R Mikrani, C Li, M Naveed, Z Liu, M Abbas… - Drug Delivery and …, 2020 - Springer
We have used a novel active hydraulic ventricular support drug delivery system (ASD)
device, which is a non-transplant surgical approach, can adhere to heart surface, and …

Therapeutic approach for global myocardial injury using bone marrow-derived mesenchymal stem cells by cardiac support device in rats

Z Liu, M Naveed, MMFA Baig, R Mikrani, C Li… - Biomedical …, 2021 - Springer
Bone marrow-derived mesenchymal stem cells (BMSCs) have been considered a promising
therapeutic approach to cardiovascular disease. This study intends to compare the effect of …