Adoptive immunotherapy with T cells, genetically modified to express a tumor-reactive
chimeric antigen receptor (CAR), is an innovative and rapidly developing life-saving …

Regulatory T cells (Tregs), a subset of CD4+ T cells marked by the expression of the
transcription factor forkhead box protein 3 (Foxp3), are pivotal in maintaining immune …

This Review explores how tumor-associated regulatory cells (Tregs) affect cancer
immunotherapy. It shows how Tregs play a role in keeping the immune system in check, how …

Background: Multiple sclerosis (MS) is an autoimmune disorder that affects the central
nervous system (CNS) through inflammation. MS symptoms become acute if the disease …

Regulatory T cells (Tregs) play a key role in suppressing systemic effector immune
responses, thereby preventing autoimmune diseases but also potentially contributing to …

Our goal is to improve the outcomes of cancer immunotherapy by targeting FOXP3+ T-
regulatory (Treg) cells with a next generation of antisense oligonucleotides (ASO), termed …

Breast cancer (BC) is a complex disease exhibiting significant heterogeneity and
encompassing various molecular subtypes. Among these, triple-negative breast cancer …

Immune responses against tumor antigens play a role in confining tumor growth. In
response, cancer cells developed several mechanisms to bypass or defeat these anti-tumor …

Keratin 7 (KRT7), also known as cytokeratin-7 (CK-7) or K7, constitutes the principal
constituent of the intermediate filament cytoskeleton and is primarily expressed in the simple …

The complex interaction between the immune system and autoinflammatory disorders
highlights the centrality of autoimmune mechanisms in the pathogenesis of …