The consequences of cerebrovascular disease are among the leading health issues
worldwide. Large and small cerebral vessel disease can trigger stroke and contribute to the …

Maintenance of brain function depends on a constant blood supply. Deficits in cerebral
blood flow are linked to cognitive decline, and they have detrimental effects on the outcome …

Abstract Endothelin-1 (ET-1) is a powerful vasoconstrictor peptide and regulator of blood
flow that plays an important role in blood pressure (BP) elevation in some models of …

The endothelins are a family of endothelium-derived peptides that possess characteristically
sustained vasoconstrictor properties. Endothelin-1 appears to be the predominant member …

The diameter of resistance arteries has a profound effect on the distribution of microvascular
blood flow and the control of systemic blood pressure. Here, we review mechanisms that …

Leptin, a protein encoded by the obese gene, is produced by adipocytes and released into
the bloodstream. In obese humans, serum leptin levels are increased and correlate with the …

Endothelins are a family of peptides, which comprises endothelin-1 (ET-1), endothelin-2 (ET-
2) and endothelin-3 (ET-3), each containing 21 amino-acids. ET-1 is a peptide secreted …

Endothelin-1 (ET-1) is overexpressed in the vascular wall in certain models of experimental
hypertension: deoxycorticosterone acetate salt–treated rats, deoxycorticosterone acetate …

The discovery of endothelin—a highly potent endogenous vasoconstrictor—in 1988 has led
to considerable efforts to develop antagonists of endothelin receptors that could have …

Endothelin receptor antagonists have been proposed for the treatment of a variety of
disorders in which the endothelins may act as pathogenic mediators, such as congestive …