Neisseria meningitidis is a gram-negative diplococcus and a transient commensal of the
human nasopharynx. It shares and competes for this niche with a number of other Neisseria …

Introduction The epidemiology of invasive meningococcal disease (IMD), a rare but
potentially fatal illness, is typically described as unpredictable and subject to sporadic …

In host-associated bacteria, surface and secreted proteins mediate acquisition of nutrients,
interactions with host cells, and specificity of tissue localization. In Gram-negative bacteria …

Clostridioides difficile is an opportunistic gut pathogen which causes severe colitis, leading
to significant morbidity and mortality due to its toxins, TcdA and TcdB. Two intra-muscular …

Mucosal vaccination aims to prevent infection mainly by inducing secretory IgA (sIgA)
antibody, which neutralises pathogens and enterotoxins by blocking their attachment to …

Factor H binding protein (fHbp) is a key virulence factor of Neisseria meningitidis and a main
component of the two licensed vaccines against serogroup B meningococcus (Bexsero and …

Neisseria meningitidis, the causative agent of invasive meningococcal disease (IMD), is
classified into different serogroups defined by their polysaccharide capsules. Meningococcal …

The only known required component of the newly described Type XI secretion system
(TXISS) is an outer membrane protein (OMP) of the DUF560 family. TXISSOMPs are broadly …

Introduction The two currently licensed surface protein non-capsular meningococcal
serogroup B (MenB) vaccines both have the purpose of providing broad coverage against …

ABSTRACT The Gram-negative pathogen Neisseria gonorrhoeae (gonococcus [Gc])
colonizes lysozyme-rich mucosal surfaces. Lysozyme hydrolyzes peptidoglycan, leading to …