[HTML][HTML] The Host-Pathogen Interactions and Epicellular Lifestyle of Neisseria meningitidis
Neisseria meningitidis is a gram-negative diplococcus and a transient commensal of the
human nasopharynx. It shares and competes for this niche with a number of other Neisseria …
human nasopharynx. It shares and competes for this niche with a number of other Neisseria …
The important lessons lurking in the history of meningococcal epidemiology
R Borrow, J Findlow - Expert Review of Vaccines, 2024 - Taylor & Francis
Introduction The epidemiology of invasive meningococcal disease (IMD), a rare but
potentially fatal illness, is typically described as unpredictable and subject to sporadic …
potentially fatal illness, is typically described as unpredictable and subject to sporadic …
A widespread bacterial secretion system with diverse substrates
AS Grossman, TJ Mauer, KT Forest, H Goodrich-Blair - MBio, 2021 - Am Soc Microbiol
In host-associated bacteria, surface and secreted proteins mediate acquisition of nutrients,
interactions with host cells, and specificity of tissue localization. In Gram-negative bacteria …
interactions with host cells, and specificity of tissue localization. In Gram-negative bacteria …
[HTML][HTML] Towards Development of a Non-Toxigenic Clostridioides difficile Oral Spore Vaccine against Toxigenic C. difficile
J Hughes, C Aston, ML Kelly, R Griffin - Pharmaceutics, 2022 - mdpi.com
Clostridioides difficile is an opportunistic gut pathogen which causes severe colitis, leading
to significant morbidity and mortality due to its toxins, TcdA and TcdB. Two intra-muscular …
to significant morbidity and mortality due to its toxins, TcdA and TcdB. Two intra-muscular …
[HTML][HTML] Mimicking Native Display of CD0873 on Liposomes Augments Its Potency as an Oral Vaccine against Clostridioides difficile
C Karyal, P Palazi, J Hughes, RC Griffiths, RR Persaud… - Vaccines, 2021 - mdpi.com
Mucosal vaccination aims to prevent infection mainly by inducing secretory IgA (sIgA)
antibody, which neutralises pathogens and enterotoxins by blocking their attachment to …
antibody, which neutralises pathogens and enterotoxins by blocking their attachment to …
Meningococcal factor H binding protein as immune evasion factor and vaccine antigen
S Principato, M Pizza, R Rappuoli - FEBS letters, 2020 - Wiley Online Library
Factor H binding protein (fHbp) is a key virulence factor of Neisseria meningitidis and a main
component of the two licensed vaccines against serogroup B meningococcus (Bexsero and …
component of the two licensed vaccines against serogroup B meningococcus (Bexsero and …
Broad vaccine protection against Neisseria meningitidis using factor H binding protein
J Findlow, CD Bayliss, PT Beernink, R Borrow… - Vaccine, 2020 - Elsevier
Neisseria meningitidis, the causative agent of invasive meningococcal disease (IMD), is
classified into different serogroups defined by their polysaccharide capsules. Meningococcal …
classified into different serogroups defined by their polysaccharide capsules. Meningococcal …
[HTML][HTML] A surface exposed, two-domain lipoprotein cargo of a type XI secretion system promotes colonization of host intestinal epithelia expressing glycans
AS Grossman, CA Escobar, EJ Mans… - Frontiers in …, 2022 - frontiersin.org
The only known required component of the newly described Type XI secretion system
(TXISS) is an outer membrane protein (OMP) of the DUF560 family. TXISSOMPs are broadly …
(TXISS) is an outer membrane protein (OMP) of the DUF560 family. TXISSOMPs are broadly …
Correlates of protection for meningococcal surface protein vaccines: current approaches for the determination of breadth of coverage
J Findlow, R Borrow, DS Stephens… - Expert Review of …, 2022 - Taylor & Francis
Introduction The two currently licensed surface protein non-capsular meningococcal
serogroup B (MenB) vaccines both have the purpose of providing broad coverage against …
serogroup B (MenB) vaccines both have the purpose of providing broad coverage against …
Effect of Lipidation on the Localization and Activity of a Lysozyme Inhibitor in Neisseria gonorrhoeae
SA Ragland, MC Gray, EM Melson… - Journal of …, 2020 - Am Soc Microbiol
ABSTRACT The Gram-negative pathogen Neisseria gonorrhoeae (gonococcus [Gc])
colonizes lysozyme-rich mucosal surfaces. Lysozyme hydrolyzes peptidoglycan, leading to …
colonizes lysozyme-rich mucosal surfaces. Lysozyme hydrolyzes peptidoglycan, leading to …