The potential of fasting-mimicking diet as a preventive and curative strategy for Alzheimer's disease

V Boccardi, M Pigliautile, AG Guazzarini, P Mecocci - Biomolecules, 2023 - mdpi.com
This review examines the potential of fasting-mimicking diets (FMDs) in preventing and
treating Alzheimer's disease (AD). FMDs are low-calorie diets that mimic the physiological …

REGULATORY ROLES OF microRNAs IN MODULATING MITOCHONDRIAL DYNAMICS, AMYLOID BETA FIBRILLATION, MICROGLIAL ACTIVATION, AND …

M Sharma, AK Tanwar, PK Purohit, P Pal… - Neuroscience & …, 2024 - Elsevier
Alzheimer's Disease (AD) remains a formidable challenge due to its complex pathology,
notably involving mitochondrial dysfunction and dysregulated microRNA (miRNA) signaling …

[HTML][HTML] Recent Advances in Therapeutics for the Treatment of Alzheimer's Disease

AM Thawabteh, AW Ghanem, S AbuMadi, D Thaher… - Molecules, 2024 - mdpi.com
The most prevalent chronic neurodegenerative illness in the world is Alzheimer's disease
(AD). It results in mental symptoms including behavioral abnormalities and cognitive …

The relationship between APOE genotype, CSF Tau and cognition across the Alzheimer's disease spectrum, moderation and mediation role of insula network …

Y Zhu, Y Wu, X Lv, J Wu, C Shen… - CNS Neuroscience …, 2024 - Wiley Online Library
Aims To investigate whether insula network connectivity modulates the relationship between
apolipoprotein E (APOE) ε4 genotype, cerebrospinal fluid (CSF) biomarkers (Aβ, Tau, and …

Examining resilience to Alzheimer's disease through the lens of monoaminergic neuromodulator systems

JL Crawford, AS Berry - Trends in Neurosciences, 2024 - cell.com
The monoaminergic nuclei are thought to be some of the earliest sites of Alzheimer's
disease (AD) pathology in the brain, with tau-containing pretangles appearing in these …

[HTML][HTML] Drug repurposing on Alzheimer's disease through modulation of NRF2 neighborhood

MM Bourdakou, R Fernández-Ginés, A Cuadrado… - Redox Biology, 2023 - Elsevier
Alzheimer's disease (AD) is an age-dependent neurodegenerative disorder and the most
common cause of cognitive decline. The alarming epidemiological features of Alzheimer's …

Novel methodology for detection and prediction of mild cognitive impairment using resting‐state EEG

J Deng, B Sun, V Kavcic, M Liu… - Alzheimer's & …, 2024 - Wiley Online Library
BACKGROUND Early discrimination and prediction of cognitive decline are crucial for the
study of neurodegenerative mechanisms and interventions to promote cognitive resiliency …

Emerging therapies for treatment of agitation, psychosis, or apathy in Alzheimer's disease

HJ Wang, A Chinna-Meyyappan… - Expert Opinion on …, 2024 - Taylor & Francis
Introduction Agitation, psychosis, and apathy are prevalent and highly distressing
neuropsychiatric symptoms (NPS) of Alzheimer's disease (AD) that have been linked to …

[HTML][HTML] AR71, Histamine H3 Receptor Ligand—In Vitro and In Vivo Evaluation (Anti-Inflammatory Activity, Metabolic Stability, Toxicity, and Analgesic Action)

A Stasiak, E Honkisz-Orzechowska, Z Gajda… - International Journal of …, 2024 - mdpi.com
The future of therapy for neurodegenerative diseases (NDs) relies on new strategies
targeting multiple pharmacological pathways. Our research led to obtaining the compound …

Toward personalized cognitive training in older adults: a pilot investigation of the effects of baseline performance and age on cognitive training outcomes

JL Bruno, JS Shaw… - Journal of Alzheimer's …, 2024 - journals.sagepub.com
Background: Cognitive training holds potential as a non-pharmacological intervention to
decrease cognitive symptoms associated with Alzheimer's disease (AD), but more research …