The intestinal epithelium forms a highly dynamic and selective barrier that controls
absorption of fluid and solutes while restricting pathogen access to underlying tissues …

Over the past two decades a growing body of evidence has demonstrated an important role
of tight junction (TJ) proteins in the physiology and disease biology of GI and liver disease …

Claudin family tight junction proteins form charge-and size-selective paracellular channels
that regulate epithelial barrier function. In the gastrointestinal tract, barrier heterogeneity is …

Endothelial tight junctions (TJs) regulate the transport of water, ions, and molecules through
the paracellular pathway, serving as an important barrier in blood vessels and maintaining …

Claudins are tight junction membrane proteins that are expressed in epithelia and
endothelia and form paracellular barriers and pores that determine tight junction …

The gastrointestinal epithelium forms the boundary between the body and external
environment. It effectively provides a selective permeable barrier that limits the permeation …

All mucosal surfaces must deal with the challenge of exposure to the outside world. The
urothelium is a highly specialized layer of stratified epithelial cells lining the inner surface of …

The intestinal epithelium is a single-cell layer that constitutes the largest and most important
barrier against the external environment. It acts as a selectively permeable barrier …

The intestinal epithelial monolayer forms a transcellular and paracellular barrier that
separates luminal contents from the interstitium. The paracellular barrier consists of a highly …

Mucosal barriers separate self from non-self and are essential for life. These barriers, which
are the first line of defense against external pathogens, are formed by epithelial cells and the …