The recent boom in microfluidics and combinatorial indexing strategies, combined with low
sequencing costs, has empowered single-cell sequencing technology. Thousands—or even …

Mathematical modelling approaches have become increasingly abundant in cancer
research. The complexity of cancer is well suited to quantitative approaches as it provides …

Intratumor heterogeneity has been widely reported in human cancers, but our knowledge of
how this genetic diversity emerges over time remains limited. A central challenge in studying …

Women with germline BRCA1 mutations (BRCA1+/mut) have increased risk for hereditary
breast cancer. Cancer initiation in BRCA1+/mut is associated with premalignant changes in …

The tumor microenvironment represents a dynamically composed matrix in which tissue-
associated cancer cells are embedded together with a variety of further cell types to form a …

Simple Summary Therapeutic functions of mesenchymal stroma-/stem-like cells (MSCs) are
mediated predominantly through paracrine effects by the release of various different …

Background The initiation and progression of malignant tumors is driven by distinct subsets
of tumor-initiating or cancer stem-like cells (CSCs) which develop therapy/apoptosis …

Genomic instability is a major driver of intra-tumor heterogeneity. However, unstable
genomes often exhibit different molecular and clinical phenotypes, which are associated …

The recently introduced genome theory of cancer evolution provides a new framework for
evolutionary studies on cancer. In particular, the established relationship between the large …

Cancer results from a sequence of genetic and epigenetic changes that lead to a variety of
abnormal phenotypes including increased proliferation and survival of somatic cells and …