It has been 50 years since Francis Fontan pioneered the operation that today bears his
name. Initially designed for patients with tricuspid atresia, this procedure is now offered for a …

Endothelial progenitor cells (EPC) may influence the integrity and stability of the vascular
endothelium. The association of an altered total EPC number and function with …

Background: The Fontan operation creates a total cavopulmonary connection, a circulation
in which the importance of pulmonary vascular resistance is magnified. Over time, this …

Background Patients with a Fontan circulation achieve lower peak heart rates (HR) during
exercise. Whether this impaired chronotropic response reflects pathology of the sinoatrial …

Background We sought to characterize body composition abnormalities in young patients
living with a Fontan circulation and explore potential pathophysiologic associations …

Background People with a Fontan circulation experience a range of physical, psychosocial
and neurodevelopmental challenges alongside, or caused by, their cardiac condition, with …

Background The optimal strategy for thromboprophylaxis in patients with a Fontan
circulation is unknown. Objectives The aim of this study was to compare the efficacy and …

Background: Despite developments in surgical techniques and medical care, people with a
Fontan circulation still experience long-term complications; non-invasive therapies to …

Background: While singular measures of socioeconomic status have been associated with
outcomes after surgery for congenital heart disease, the multifaceted pathways through …

Aims The role of cardiopulmonary exercise testing (CPET) in predicting major adverse
cardiovascular events (MACE) in people with congenital heart disease (ConHD) is …