Single and combined strategies for mesenchymal stem cell exosomes alleviate liver fibrosis: a systematic review and meta-analysis of preclinical animal models

X Zhou, Y Xu, X Wang, W Lu, X Tang, Y Jin… - Frontiers in …, 2024 - frontiersin.org
Background: The efficacy of mesenchymal stem cells (MSCs) in treating liver fibrosis has
been supported by various clinical studies. However, stem cell transplantation is limited in …

[HTML][HTML] Comparative Analysis of Exosomes and Extracellular Microvesicles in Healing Pathways: Insights for Advancing Regenerative Therapies

M Sędzik, K Rakoczy, J Sleziak, M Kisiel, K Kraska… - Molecules, 2024 - mdpi.com
Exosomes and microvesicles bear great potential to broaden therapeutic options in the
clinical context. They differ in genesis, size, cargo, and composition despite their similarities …

Innovative preconditioning strategies for improving the therapeutic efficacy of extracellular vesicles derived from mesenchymal stem cells in gastrointestinal diseases

MA Didamoony, AA Soubh, AM Atwa, LA Ahmed - Inflammopharmacology, 2023 - Springer
Gastrointestinal (GI) diseases have become a global health issue and an economic burden
due to their wide distribution, late prognosis, and the inefficacy of recent available …

Ampelopsis grossedentata tea alleviating liver fibrosis in BDL-induced mice via gut microbiota and metabolite modulation

YY Xi, C Chen, JJ Zheng, B Jiang, XY Dong… - npj Science of …, 2024 - nature.com
Liver fibrosis (LF) is a common sequela to diverse chronic liver injuries, leading to rising
rates of cirrhosis and hepatocellular carcinoma (HCC). As the medicinal and edible …

Native and engineered extracellular vesicles: novel tools for treating liver disease

S Jiang, S Tian, P Wang, J Liu, K Sun, X Zhou… - Journal of Materials …, 2024 - pubs.rsc.org
Liver diseases are classified as acute liver damage and chronic liver disease, with recurring
liver damage causing liver fibrosis and progression to cirrhosis and hepatoma. Liver …

[HTML][HTML] Progress of mesenchymal stem cells (MSCs) & MSC-Exosomes combined with drugs intervention in liver fibrosis

Y Xu, X Zhou, X Wang, Y Jin, L Zhou, J Ye - Biomedicine & …, 2024 - Elsevier
Liver fibrosis is an intrahepatic chronic damage repair response caused by various reasons
such as alcoholic liver, fatty liver, viral hepatitis, autoimmune diseases, etc., and is closely …

The regulatory role and mechanism of exosomes in hepatic fibrosis

Y Yao, D Chen, Z Yue - Frontiers in Pharmacology, 2023 - frontiersin.org
Globally, the prevalence and fatality rates of liver disorders are on the rise. Among chronic
liver conditions, hepatic fibrosis stands out as a central pathological process. Despite this …

[HTML][HTML] Advances in the treatment of liver injury based on mesenchymal stem cell-derived exosomes

C Hu, L Wang - Stem Cell Research & Therapy, 2024 - pmc.ncbi.nlm.nih.gov
Mesenchymal stem cells (MSCs) have shown a great potential role in treating liver injury.
MSCs can promote liver regeneration by differentiating into hepatocytes, and can also …

Protective effect of rupatadine on testicular ischemia/reperfusion injury in rats: Modulation of IL-6/STAT3, Akt/mTOR signaling pathways

AM Abdel-Aziz, AA Abdelmonaem, DM Thabit… - Toxicology and Applied …, 2024 - Elsevier
Backgrounds & aim Spermatic cord rotation is a common problem in the field of urology, that
finally results in necrosis of testicular tissue as well as male infertility. Rupatadine (RUP); a …

Inhibition of Adipocyte Necroptosis Alleviates Fat Necrosis and Fibrosis after Grafting: In a Mice Model

X Liu, Y Yao, Y Zhu, F Lu, X Chen - Aesthetic Surgery Journal, 2024 - academic.oup.com
Background Owing to the delicate structure of the adipose tissue, fat necrosis accounts for
43.7% of all complications after autologous fat grafting; however, its regulation remains …