Supervised machine learning for population genetics: a new paradigm

DR Schrider, AD Kern - Trends in Genetics, 2018 - cell.com
As population genomic datasets grow in size, researchers are faced with the daunting task
of making sense of a flood of information. To keep pace with this explosion of data …

Fitness, growth and transmissibility of SARS-CoV-2 genetic variants

E Volz - Nature Reviews Genetics, 2023 - nature.com
The massive scale of the global SARS-CoV-2 sequencing effort created new opportunities
and challenges for understanding SARS-CoV-2 evolution. Rapid detection and assessment …

PopGenome: an efficient Swiss army knife for population genomic analyses in R

B Pfeifer, U Wittelsbürger… - Molecular biology …, 2014 - academic.oup.com
Although many computer programs can perform population genetics calculations, they are
typically limited in the analyses and data input formats they offer; few applications can …

DnaSP, DNA polymorphism analyses by the coalescent and other methods

J Rozas, JC Sánchez-DelBarrio, X Messeguer… - …, 2003 - academic.oup.com
DnaSP is a software package for the analysis of DNA polymorphism data. Present version
introduces several new modules and features which, among other options allow:(1) …

Molecular signatures of natural selection

R Nielsen - Annu. Rev. Genet., 2005 - annualreviews.org
There is an increasing interest in detecting genes, or genomic regions, that have been
targeted by natural selection. The interest stems from a basic desire to learn more about …

The unreasonable effectiveness of convolutional neural networks in population genetic inference

L Flagel, Y Brandvain… - Molecular biology and …, 2019 - academic.oup.com
Population-scale genomic data sets have given researchers incredible amounts of
information from which to infer evolutionary histories. Concomitant with this flood of data …

Nationwide genomic atlas of soil-dwelling Listeria reveals effects of selection and population ecology on pangenome evolution

J Liao, X Guo, DL Weller, S Pollak, DH Buckley… - Nature …, 2021 - nature.com
Natural bacterial populations can display enormous genomic diversity, primarily in the form
of gene content variation caused by the frequent exchange of DNA with the local …

Soft sweeps are the dominant mode of adaptation in the human genome

DR Schrider, AD Kern - Molecular biology and evolution, 2017 - academic.oup.com
The degree to which adaptation in recent human evolution shapes genetic variation remains
controversial. This is in part due to the limited evidence in humans for classic “hard selective …

Genetic analyses of atypical Toxoplasma gondii strains reveal a fourth clonal lineage in North America

A Khan, JP Dubey, C Su, JW Ajioka… - International journal for …, 2011 - Elsevier
Toxoplasma gondii is a widespread parasite of animals that causes zoonotic infections in
humans. Previous studies have revealed a strongly clonal population structure in North …

Linkage disequilibrium as a signature of selective sweeps

Y Kim, R Nielsen - Genetics, 2004 - academic.oup.com
The hitchhiking effect of a beneficial mutation, or a selective sweep, generates a unique
distribution of allele frequencies and spatial distribution of polymorphic sites. A composite …