Synaptic plasticity is an important cellular mechanism for the formation of memory in
neuronal circuits of the brain. Research during the past two decades has revealed …

Phosphorylation of proteins is reversibly controlled by the kinases and phosphatases in
many posttranslational regulation patterns. Protein phosphatase 5 (PPP5C) is a …

Abnormal hyperphosphorylation of tau is believed to lead to neurofibrillary degeneration in
Alzheimer's disease (AD) and other tauopathies. Recent studies have shown that protein …

Neurofibrillary tangles (NFTs) made up of hyperphosphorylated tau are a histopathological
hallmark of Alzheimer's disease (AD) and related tauopathies. Hyperphosphorylation of tau …

Tau is a neuronal microtubule‐associated protein. Its hyperphosphorylation plays a critical
role in Alzheimer disease (AD). Expression and phosphorylation of tau are regulated …

A disturbance of calcium homeostasis is believed to play an important role in the
neurodegeneration of the brains of Alzheimer disease (AD) patients, but the molecular …

Protein phosphatase (PP) 5 is highly expressed in the mammalian brain, but few
physiological substrates have yet been identified. Here, we investigated the kinetics of …

The cAMP-dependent protein kinase (PKA) controls a large number of cellular functions.
One critical PKA substrate in the brain and heart is the L-type Ca2+ channel Cav1. 2, the …

The molecular oscillator that drives circadian rhythmicity in mammals obtains its near 24-h
periodicity from posttranslational regulation of clock proteins. Activity of the major clock …

Microtubule-associated protein tau is hyperphosphorylated and aggregated in affected
neurons in Alzheimer disease (AD) brains. The tau pathology starts from the entorhinal …