The Canadian consensus guidelines on OA treatment were created from a diverse group of
experts, with a strong clinical and/or academic background in treating OA in dogs. The …

This review highlights the attributes of pentosan polysulfate (PPS) in the promotion of
intervertebral disc (IVD) repair processes. PPS has been classified as a disease-modifying …

Abstract Rubiadin-1-methyl ether (RBM) is a natural anthraquinone compound isolated from
the root of Morinda officinalis How. In our previous study, RBM was found to have inhibitory …

Background Fibrous dysplasia (FD) is a bone marrow stromal cell (BMSC) disease caused
by activating mutations of guanine nucleotide-binding protein alpha-stimulating activity …

Gaucher and Fabry diseases are the most prevalent sphingolipidoses. Chronic inflammation
is activated in those disorders, which could play a role in pathogenesis. Significant degrees …

Hepcidin which is the crucial regulator of iron homeostasis, produced in the liver in response
to anemia, hypoxia, or inflammation. Recent studies have suggested that hepcidin and iron …

Bears do not suffer from osteoporosis during hibernation, which is associated with long-term
inactivity, lack of food intake, and cold exposure. However, the mechanisms involved in …

This chapter proposes a proactive, preventive multimodal pain management strategy,
introduces a “tiered decision tree” to prioritize evidence‐based therapy, and critically …

Suitably protected mono-and di-saccharide residues associated with the glucuronic acid-
containing repeat unit related to pentosan polysulfate have been prepared. The stereo …

Bone has good innate healing potential but faces increased morbidity, and in extensive
bone damage, infections, or in systemic affections, the said potential is delayed (delayed …