Abstract CRISPR/Cas9 (Clustered Regularly Interspaced Short Palindromic Repeats-
associated protein 9) is a potent technology for gene-editing. Owing to its high specificity …

Neurodegenerative diseases (NDs) represent a heterogeneous group of aging-related
disorders featured by progressive impairment of motor and/or cognitive functions, often …

Myocardial infarction is lethal to patients because of insufficient blood perfusion to vital
organs. Several attempts have been made to improve its prognosis, among which …

Nasal administration offers a possibility of delivering drugs to the brain. In the present work,
nasal drug delivery systems were designed based on cationic Eudragit® EPO (EPO) and …

This advanced review describes the anatomical and physiological barriers and mechanisms
impacting nanomedicine translocation from the nasal cavity directly to the brain. There are …

Mutations on the epidermal growth factor receptor (EGFR), induction of angiogenesis, and
reprogramming cellular energetics are all biological features acquired by tumor cells during …

Bexarotene, a retinoid X receptor (RXR) agonist, is approved by FDA to treat cutaneous T-
cell lymphoma. However, it has also demonstrated promising therapeutic potential for …

Purpose We designed a novel isoliquiritigenin (ISL) loaded micelle prepared with DSPE-
PEG 2000 as the drug carrier modified with the brain-targeting polypeptide angiopep-2 to …

Due to the special physiological and pathological characteristics of gliomas, most
therapeutic drugs are prevented from entering the brain. To improve the poor prognosis of …

Neuroprotection in cerebral ischemia (CI) has received increasing attention. However,
efficient delivery of therapeutic agents to the brain remains a major challenge due to the …