The Homer family of adaptor proteins consists of three members in mammals, and homologs
are also known in other animals but not elsewhere. They are predominantly localized at the …

Alterations in synaptic signaling and plasticity occur during the refinement of neural circuits
over the course of development and the adult processes of learning and memory. Synaptic …

The postsynaptic density (PSD) is crucial for synaptic functions, but the molecular
architecture retaining its structure and components remains elusive. Homer and Shank are …

Receptor signaling at the plasma membrane often releases calcium from intracellular stores.
For example, inositol triphosphate (IP3) produced by receptor-coupled phospholipase C …

Homer proteins mediate molecular rearrangements leading to changes in spine
morphology. This points to a role of Homer in learning and memory. Homer 1c features both …

Homers are scaffolding proteins that bind Ca2+ signaling proteins in cellular microdomains.
The Homers participate in targeting and localization of Ca2+ signaling proteins in signaling …

Homer is a crucial postsynaptic scaffolding protein involved in both maintenance and activity-
induced plasticity of the synapse. However, its quaternary structure has yet to be …

Abnormal metabotropic glutamate receptor 5 (mGluR5) function, as a result of disrupted
scaffolding with its binding partner Homer, contributes to the pathophysiology of fragile X …

Glutamate mediates most excitatory synaptic transmission in the brain. Synaptic strength at
glutamatergic synapses shows a remarkable degree of use-dependent plasticity and such …

Background Homer is a postsynaptic scaffold protein that links various synaptic signaling
proteins, including the type I metabotropic glutamate receptor subunits 1α and 5, the inositol …