Inhibition of carbonic anhydrase (CA, EC 4.2. 1.1) was clinically exploited for decades, as
most modern diuretics were obtained considering as lead molecule acetazolamide, the …

Abstract Carbonic anhydrases (CAs, EC 4.2. 1.1) are widely distributed metalloenzymes in
both prokaryotes and eukaryotes. They efficiently catalyze the reversible hydration of carbon …

To provide guidance to clinicians about best preventive and therapeutic practices, the
Wilderness Medical Society (WMS) convened an expert panel to develop evidence-based …

Alveolar hypoxia is the most prominent feature of high altitude environment with well-known
consequences for the cardio-pulmonary system, including development of pulmonary …

To provide guidance to clinicians about best practices, the Wilderness Medical Society
convened an expert panel to develop evidence-based guidelines for prevention and …

To provide guidance to clinicians about best practices, the Wilderness Medical Society
(WMS) convened an expert panel to develop evidence-based guidelines for the prevention …

Abstract Swenson, Erik R. Hypoxic pulmonary vasoconstriction. High Alt Med Biol 14: 101–
110, 2013.—Hypoxic pulmonary vasoconstriction (HPV) continues to fascinate …

High-altitude pulmonary edema (HAPE) is an uncommon form of pulmonary edema that
occurs in healthy individuals within a few days of arrival at altitudes above 2,500–3,000 m …

Amid efforts to care for the large number of patients with coronavirus disease (COVID-19),
there has been considerable speculation about whether the lung injury seen in these …

High-altitude illnesses have profound consequences on the health of many unsuspecting
and otherwise healthy individuals who sojourn to high altitude for recreation and work. The …