Aging can be defined as progressive functional decline and increasing mortality over time.
Here, we review evidence linking aging to nuclear DNA lesions: DNA damage accumulates …

Coordinated progression through the cell cycle is a complex challenge for eukaryotic cells.
Following genotoxic stress, diverse molecular signals must be integrated to establish …

Background Genomic DNA copy number aberrations are frequent in solid tumors, although
the underlying causes of chromosomal instability in tumors remain obscure. Genes likely to …

Breast cancer is a heterogeneous disease, appreciable by molecular markers, gene-
expression profiles, and most recently, patterns of genomic alteration. In particular, genomic …

In this study, we examine the potential role of receptor-associated protein 80 (RAP80), a
nuclear protein containing two ubiquitin-interacting motifs (UIM), in DNA damage response …

Inherited mutations of the breast cancer susceptibility gene BRCA1 confer a high risk for
breast cancer development. The 300RXKK and 266KXK motifs have been identified …

In budding yeast, the Rad9 protein is an important player in the maintenance of genomic
integrity and has a well-characterised role in DNA damage checkpoint activation. Recently …

Based on abscisic acid (ABA) inhibition of seed germination and seedling growth assays,
we isolated an ABA overly sensitive mutant (abo4-1) caused by a mutation in the …

An integrated cellular response to DNA damage is essential for the maintenance of genome
integrity. Recently, post‐translational modifications to histone proteins have been implicated …

Fanconi anemia (FA) is an autosomal and X-linked recessive disorder characterized by
bone marrow failure, acute myelogenous leukemia, solid tumors, and developmental …