Collagens mediate essential hemostasis by maintaining the integrity and stability of the
vascular wall. Imbalanced turnover of collagens by uncontrolled formation and/or …

Collagens represent up to 40% of the total protein of the vessel wall, forming an insoluble
scaffold which is essential for tissue integrity and which provides a surface for the …

Fibrin, the coagulation end product, consolidates the platelet plug at sites of vascular injury
and supports the recruitment of circulating platelets. In addition to integrin αIIbβ3, another as …

Glycoprotein (GP) Ibα of the GPIb-IX–V complex and GPVI bind von Willebrand factor (vWF)
and collagen, respectively, and are critical for the initial interaction of circulating platelets …

Assays measuring platelet aggregation (thrombus formation) at arterial shear rate mostly
use collagen as only platelet-adhesive surface. Here we report a multi-surface and multi …

Collagen-rich extracellular matrices are abundant and ubiquitous in the mammalian body.
Collagens are not only essential for the mechanical stability of tissues, but are also …

Platelet glycoprotein VI (GPVI) is attracting interest as a potential target for the development
of new antiplatelet molecules with a low bleeding risk. GPVI binding to vascular collagen …

Platelets perform a central role in haemostasis and thrombosis. They adhere to
subendothelial collagens exposed at sites of blood vessel injury via the glycoprotein (GP) Ib …

Glycoprotein (GP) VI is a platelet membrane protein with a molecular weight of 62 kDa that
was identified as a physiological collagen receptor from studies of patients deficient in this …

Essentials• Dimeric high‐affinity collagen receptor glycoprotein VI (GPVI) is present on
resting platelets.• Spatio‐temporal organization of platelet GPVI‐dimers was evaluated …