Progress in the research of GPIIb/IIIa antagonists
Z Xie, C Cao, S Feng, J Huang, Z Li - Future medicinal chemistry, 2015 - Taylor & Francis
This review covers the recent advances in the development of small RGD (Arg-Gly-Asp
sequence) containing peptides and their mimetics as potential antithrombotic agents …
sequence) containing peptides and their mimetics as potential antithrombotic agents …
Effect of synthetic peptides corresponding to residues 313–332 of the αIIb subunit on platelet activation and fibrinogen binding to αIIbβ3
JV Mitsios, AP Tambaki, M Abatzis… - European journal of …, 2004 - Wiley Online Library
The platelet integrin receptor αIIbβ3 plays a critical role in thrombosis and haemostasis by
mediating interactions between platelets and several ligands but primarily fibrinogen. It has …
mediating interactions between platelets and several ligands but primarily fibrinogen. It has …
The relative orientation of the Arg and Asp side chains defined by a pseudodihedral angle as a key criterion for evaluating the structure–activity relationship of RGD …
The ability of an integrin to distinguish between the RGD‐containing extracellular matrix
proteins is thought to be due partially to the variety of RGD conformations. Three criteria …
proteins is thought to be due partially to the variety of RGD conformations. Three criteria …
The anti‐platelet approach targeting the fibrinogen ligand of the GPIIb/IIIa receptor
V Tsikaris - Journal of Peptide Science: An Official Publication …, 2004 - Wiley Online Library
Activation of the platelet surface receptor GPIIb/IIIa is the final pathway of platelet
aggregation, regardless of the initiating stimulus. RGD analogues, peptidomimetics and …
aggregation, regardless of the initiating stimulus. RGD analogues, peptidomimetics and …
[HTML][HTML] Highly constrained cyclic (S, S)-CXaaC-peptides as inhibitors of fibrinogen binding to platelets
A Kouki, JV Mitsios, M Sakarellos-Daitsiotis… - Journal of Thrombosis …, 2005 - Elsevier
Summary The Arg-Gly-Asp RGD motif of adhesive proteins is recognized by the activated
platelet integrin α IIb β 3. Binding of fibrinogen (Fg) to activated α IIb β 3 causes platelet …
platelet integrin α IIb β 3. Binding of fibrinogen (Fg) to activated α IIb β 3 causes platelet …
Computational modelling and molecular dynamics simulations of a cyclic peptide mimotope of the CD52 antigen complexed with CAMPATH-1H antibody
A Stavrakoudis - Molecular Simulation, 2010 - Taylor & Francis
A peptide mimotope of the CD52 antigen with the sequence T1SSPSAD7 has been co-
crystallised with the CAMPATH-1H antibody. Molecular dynamics (MD) simulations in …
crystallised with the CAMPATH-1H antibody. Molecular dynamics (MD) simulations in …
The Ac–RGD–NH2 peptide as a probe of slow conformational exchange of short linear peptides in DMSO
According to general belief, the conformational information on short linear peptides in
solution derived at ambient temperature from NMR spectrometry represents a population …
solution derived at ambient temperature from NMR spectrometry represents a population …
A highly constrained cyclic (S, S)-CDC-peptide is a potent inhibitor of carotid artery thrombosis in rabbits
VD Roussa, EM Stathopoulou, ND Papamichael… - Platelets, 2011 - Taylor & Francis
Inhibition of platelet aggregation is indispensable for the treatment of acute arterial
thrombotic episodes. We have previously reported the synthesis of a highly constrained …
thrombotic episodes. We have previously reported the synthesis of a highly constrained …
The mimetics of antiadhesive peptides as the inhibitors of Mycibacterium kansasii phagocytosis
IZ Siemion, M Gawłowska, K Ślepokura, M Biernat… - Peptides, 2005 - Elsevier
The α-guanidino acids derived of 15 proteinaceous amino acids, ω-guanidino acids with
gradually increased hydrocarbon chains, and amidinated dipeptides, were tested as the …
gradually increased hydrocarbon chains, and amidinated dipeptides, were tested as the …
Investigation of the role of adjacent amino acids to the 313–320 sequence of the αIIb subunit on platelet activation and fibrinogen binding to αIIbβ3
JV Mitsios, G Stamos, FI Rodis, LD Tsironis… - Platelets, 2006 - Taylor & Francis
The platelet integrin receptor αIIbβ3 plays a critical role in thrombosis and haemostasis by
mediating interactions between platelets and several ligands, primarily fibrinogen. We have …
mediating interactions between platelets and several ligands, primarily fibrinogen. We have …