Molecular biology, epidemiology, and pathogenesis of progressive multifocal leukoencephalopathy, the JC virus-induced demyelinating disease of the human brain

MW Ferenczy, LJ Marshall, CDS Nelson… - Clinical microbiology …, 2012 - Am Soc Microbiol
Progressive multifocal leukoencephalopathy (PML) is a debilitating and frequently fatal
central nervous system (CNS) demyelinating disease caused by JC virus (JCV), for which …

Progressive multifocal leukoencephalopathy: current treatment options and future perspectives

D Pavlovic, AC Patera, F Nyberg… - Therapeutic …, 2015 - journals.sagepub.com
Progressive multifocal leukoencephalopathy (PML) is a rare but debilitating and frequently
fatal viral disease of the central nervous system, primarily affecting individuals with …

HIV-associated opportunistic infections of the CNS

IL Tan, BR Smith, G von Geldern, FJ Mateen… - The Lancet …, 2012 - thelancet.com
Survival in people infected with HIV has improved because of an increasingly powerful array
of antiretroviral treatments, but neurological symptoms due to comorbid conditions, including …

Development of CMX001 (Brincidofovir) for the treatment of serious diseases or conditions caused by dsDNA viruses

DF Florescu, MA Keck - Expert review of anti-infective therapy, 2014 - Taylor & Francis
CMX001 (hexadecyloxypropyl-cidofovir, Brincidofovir) is a broad spectrum, lipid conjugate
of cidofovir that is converted intracellularly into the active antiviral, cidofovir diphosphate …

[HTML][HTML] In vitro comparison of currently available and investigational antiviral agents against pathogenic human double-stranded DNA viruses: A systematic literature …

RF Chemaly, JA Hill, S Voigt, KS Peggs - Antiviral Research, 2019 - Elsevier
Background Double-stranded (ds) DNA virus infections often occur concomitantly in
immunocompromised patients. We performed a systematic search of published in vitro …

Advances in the development of antiviral strategies against parvovirus B19

E Manaresi, G Gallinella - Viruses, 2019 - mdpi.com
Parvovirus B19 (B19V) is a human pathogenic virus, responsible for an ample range of
clinical manifestations. Infections are usually mild, self-limiting, and controlled by the …

[HTML][HTML] Development of CMX001 for the treatment of poxvirus infections

R Lanier, L Trost, T Tippin, B Lampert, A Robertson… - Viruses, 2010 - ncbi.nlm.nih.gov
Abstract CMX001 (phosphonic acid,[[(S)-2-(4-amino-2-oxo-1 (2H)-pyrimidinyl)-1-
(hydroxymethyl) ethoxy] methyl] mono [3-(hexadecyloxy) propyl] ester) is a lipid conjugate of …

Human polyomavirus reactivation: disease pathogenesis and treatment approaches

CF De Gascun, MJ Carr - Journal of Immunology Research, 2013 - Wiley Online Library
JC and BK polyomaviruses were discovered over 40 years ago and have become
increasingly prevalent causes of morbidity and mortality in a variety of distinct …

Highlights in antiviral drug research: antivirals at the horizon

ED Clercq - Medicinal Research Reviews, 2013 - Wiley Online Library
This review highlights ten “hot topics” in current antiviral research:(i) new nucleoside
derivatives (ie, PSI‐352938) showing high potential as a direct antiviral against hepatitis C …

[HTML][HTML] Guidelines for the prevention and treatment of opportunistic infections in HIV-exposed and HIV-infected children: recommendations from the National Institutes …

GK Siberry, MJ Abzug, S Nachman… - The Pediatric …, 2013 - ncbi.nlm.nih.gov
This report updates the last version of the Guidelines for the Prevention and Treatment of
Opportunistic Infections (OIs) in HIV-Exposed and HIV-Infected Children, published in 2009 …