Abstract The WHO (World Health Organization) manuals provide state-of-the-art guidance
on how a semen analysis should be carried out. The much anticipated sixth edition of the …

Abstract Infertility affects 8–12% of couples globally, and the male factor is a primary cause
in~ 50% of couples. Male infertility is a multifactorial reproductive disorder, which can be …

Context Our previous study showed that paternal subclinical hypothyroidism (SCH) had a
detrimental effect on the clinical outcomes of assisted reproductive technologies. However, it …

Emerging evidence has shown that cell-cell interactions between testicular cells, in
particular at the Sertoli cell-cell and Sertoli-germ cell interface, are crucial to support …

Although localized haploid phasing can be achieved using long read genome sequencing
without parental data, reliable chromosome-scale phasing remains a great challenge. Given …

Semen evaluation began in 1677 when Dutch scientist Anton van Leeuwenhoek and his
student Johan Ham viewed a human ejaculate under a compound microscope …

Microfluidics offers tremendous opportunities to understand the underlying biology of
fertilization at the single-cell level and improve infertility management, however, its true …

Background Protamination and condensation of sperm chromatin as well as DNA integrity
play an essential role during fertilization and embryo development. In some mammals, like …

Intracytoplasmic sperm injection (ICSI) using surgically retrieved spermatozoa outside the
classic context of azoospermia has been increasingly used to overcome infertility. The …

The rheological behavior of human semen is overlooked and essentially unexplored in the
scientific literature. Here, we provide the first quantitative experimental evidence that post …