Injectable hydrogels are one of the most widely investigated and versatile technologies for
drug delivery and tissue engineering applications. Hydrogels' versatility arises from their …

The complex interaction of cells with biomaterials (ie, materiobiology) plays an increasingly
pivotal role in the development of novel implants, biomedical devices, and tissue …

Currently, the treatment of corneal diseases caused by damage to the corneal endothelium
requires a donor cornea. Because of their limited availability (1 donor cornea for 70 patients …

Background Retinal pigment epithelium (RPE) cell therapy is a promising way to treat many
retinal diseases. However, obtaining transplantable RPE cells is time-consuming and less …

In vitro differentiation of human pluripotent stem cells (hPSCs) into specialized tissues and
organs represents a powerful approach to gain insight into those cellular and molecular …

The immune system is increasingly recognized as an important regulator of tissue repair. We
developed a regenerative immunotherapy from the helminth Schistosoma mansoni soluble …

Retinal degenerative diseases are a major cause of blindness involving the dysfunction of
photoreceptors, retinal pigmented epithelium (RPE), or both. A promising treatment …

Wounds and the healing process are one of the main concerns of medical science today. A
wound is any loss of integrity, or rupture of the layers of skin (epidermis, dermis, and …

Physiologically relevant in vitro models of the human outer retina are required to better
elucidate the complex interplay of retinal tissue layers and investigate their role in retinal …

In this study, we show that undirected differentiation of human embryonic stem cells (hESC)
to retinal pigment epithelium (RPE) acts as a selective barrier against aneuploid cells. Large …