Insights into the drug screening approaches in leishmaniasis
Leishmaniasis, a tropically neglected disease, is responsible for the high mortality and
morbidity ratio in poverty-stricken areas. Currently, no vaccine is available for the complete …
morbidity ratio in poverty-stricken areas. Currently, no vaccine is available for the complete …
Virulence factors of Leishmania parasite: Their paramount importance in unraveling novel vaccine candidates and therapeutic targets
Leishmaniasis is a neglected tropical disease and remains a global concern for healthcare.
It is caused by an opportunistic protozoan parasite belonging to the genus Leishmania and …
It is caused by an opportunistic protozoan parasite belonging to the genus Leishmania and …
[HTML][HTML] An immunoinformatic approach driven by experimental proteomics: in silico design of a subunit candidate vaccine targeting secretory proteins of Leishmania …
Background Visceral leishmaniasis (VL) caused by dimorphic Leishmania species is a
parasitic disease with high socioeconomic burden in endemic areas worldwide. Sustaining …
parasitic disease with high socioeconomic burden in endemic areas worldwide. Sustaining …
[HTML][HTML] Leishmania Vesicle-Depleted Exoproteome: What, Why, and How?
S Esteves, I Costa, S Luelmo, N Santarém… - Microorganisms, 2022 - mdpi.com
Leishmaniasis, a vector-borne parasitic protozoan disease, is among the most important
neglected tropical diseases. In the absence of vaccines, disease management is …
neglected tropical diseases. In the absence of vaccines, disease management is …
Leishmania (L.) amazonensis LaLRR17 increases parasite entry in macrophage by a mechanism dependent on GRP78
MS Peña, FHF Tang, FA de Lima Franco… - Parasitology, 2023 - cambridge.org
Leishmaniases affect 12 million people worldwide. They are caused by Leishmania spp.,
protozoan parasites transmitted to mammals by female phlebotomine flies. During the life …
protozoan parasites transmitted to mammals by female phlebotomine flies. During the life …
[HTML][HTML] Experimental strategies to explore drug action and resistance in kinetoplastid parasites
M Van den Kerkhof, YGJ Sterckx, P Leprohon, L Maes… - Microorganisms, 2020 - mdpi.com
Kinetoplastids are the causative agents of leishmaniasis, human African trypanosomiasis,
and American trypanosomiasis. They are responsible for high mortality and morbidity in …
and American trypanosomiasis. They are responsible for high mortality and morbidity in …
[HTML][HTML] Applied proteomics in 'one health'
'One Health'summarises the idea that human health and animal health are interdependent
and bound to the health of ecosystems. The purpose of proteomics methodologies and …
and bound to the health of ecosystems. The purpose of proteomics methodologies and …
Proteomic Analysis of the Promastigote Secretome of Seven Leishmania Species
J Pissarra, J Pagniez, E Petitdidier… - Journal of Proteome …, 2021 - ACS Publications
Leishmaniasis is one of the most impactful parasitic diseases worldwide, endangering the
lives of 1 billion people every year. There are 20 different species of Leishmania able to …
lives of 1 billion people every year. There are 20 different species of Leishmania able to …
[HTML][HTML] Proteomic Analysis of Leishmania donovani Membrane Components Reveals the Role of Activated Protein C Kinase in Host-Parasite Interaction
Visceral leishmaniasis (VL), mainly caused by the Leishmania donovani parasitic infection,
constitutes a potentially fatal disease, for which treatment is primarily dependent on …
constitutes a potentially fatal disease, for which treatment is primarily dependent on …
[HTML][HTML] Differentially modulated proteins associated with Leishmaniasis—a systematic review of in-vivo and in-vitro studies
R Ranjan, P Das, S Vijayakumar - Molecular Biology Reports, 2020 - Springer
High-throughput proteomic technologies are widely used for understanding the disease
mechanism, drug-resistant mechanism, and to identify drug targets and markers for …
mechanism, drug-resistant mechanism, and to identify drug targets and markers for …