Diseases of the central nervous system (CNS) remain a significant health, social and
economic problem around the globe. The development of therapeutic strategies for CNS …

Accumulating evidence suggests that the gut microbiome influences the brain functions and
psychological state of its host via the gut–brain axis, and gut dysbiosis has been linked to …

Considerable data relate major depressive disorder (MDD) with aberrant immune system
functioning. Pro-inflammatory cytokines facilitate metabolism of tryptophan along the …

Regulation of emotions is generally associated exclusively with the brain. However, there is
evidence that peripheral systems are also involved in mood, stress vulnerability vs …

Objective Disturbances in the kynurenine pathway have been implicated in the
pathophysiology of psychotic and mood disorders, as well as several other psychiatric …

Background There is now evidence that affective disorders including major depressive
disorder (MDD) and bipolar disorder (BD) are mediated by immune-inflammatory and nitro …

Major depressive disorder (MDD) and bipolar disorder (BD) with melancholia and psychotic
features and suicidal behaviors are accompanied by activated immune-inflammatory and …

The kynurenine pathway of tryptophan degradation produces several neuroactive
metabolites such as kynurenic acid (KYNA), quinolinic acid (QUIN), and picolinic acid (PIC) …

The relationship between gut microbiota (GM) and mental health is one of the focuses of
psychobiology research. In recent years, the microbial-gut-brain axis (MGBA) concept has …

Background Altered glutamatergic neurotransmission and neuropeptide levels play a central
role in migraine pathomechanism. Previously, we confirmed that kynurenic acid, an …