Estimating the effects of variants found in disease driver genes opens the door to
personalized therapeutic opportunities. Clinical associations and laboratory experiments …

Mutations are at the root of many human diseases. Still, we largely do not exactly
understand how they trigger pathogenesis. One, more recent, hypothesis has been that they …

Technological and computational advances in genomics and interactomics have made it
possible to identify how disease mutations perturb protein–protein interaction (PPI) networks …

AMPA receptors (AMPARs) are tetrameric ligand-gated channels made up of combinations
of GluA1-4 subunits encoded by GRIA1-4 genes. GluA2 has an especially important role …

Phosphorylation is one of the most dynamic and widespread post‐translational
modifications regulating virtually every aspect of eukaryotic cell biology. Here, we assemble …

Phenotype robustness to environmental fluctuations is a common biological phenomenon.
Although most phenotypes involve multiple proteins that interact with each other, the basic …

Autism spectrum disorder (ASD) is a neurodevelopmental disorder with a strong genetic
component. Recently developed genomic technologies, including microarray and next …

Connectivity webs mediate the unique biology of the mammalian brain. Yet, while cell circuit
maps are increasingly available, knowledge of their underlying molecular networks remains …

Neurodevelopmental disorders (NDDs) are a group of disorders in which the development
of the central nervous system (CNS) is disturbed, resulting in different neurological and …

There are hundreds of risk genes associated with autism spectrum disorder (ASD), but
signaling networks at the protein level remain unexplored. We use neuron-specific proximity …