Phosphatase and Tensin Homolog deleted on Chromosome 10 (PTEN) is a dual
phosphatase with both protein and lipid phosphatase activities. PTEN was first discovered …

PTEN is the most important negative regulator of the PI3K signaling pathway. In addition to
its canonical, PI3K inhibition-dependent functions, PTEN can also function as a tumor …

The development of life-threatening cancer metastases at distant organs requires
disseminated tumour cells' adaptation to, and co-evolution with, the drastically different …

The phosphatidylinositol 3-kinase (PI3K)/AKT/mammalian target of the rapamycin (mTOR)
signalling pathway is hyperactivated or altered in many cancer types and regulates a broad …

Regulation of the PI-3 kinase (PI3K)/Akt signalling pathway is essential for maintaining the
integrity of fundamental cellular processes, cell growth, survival, death and metabolism, and …

Peripheral T-cell lymphoma (PTCL) is a group of complex clinicopathological entities, often
associated with an aggressive clinical course. Angioimmunoblastic T-cell lymphoma (AITL) …

The importance of PTEN in cellular function is underscored by the frequency of its
deregulation in cancer. PTEN tumor-suppressor activity depends largely on its lipid …

Mutational activation of BRAF is the earliest and most common genetic alteration in human
melanoma. To build a model of human melanoma, we generated mice with conditional …

PI3-kinase and PTEN are major positive and negative regulators, respectively, of the PI3-
kinase pathway, which regulates growth, survival, and proliferation. These key signaling …

Cellular senescence has been theorized to oppose neoplastic transformation triggered by
activation of oncogenic pathways in vitro,,, but the relevance of senescence in vivo has not …