[HTML][HTML] Epigenetic regulation of the histone-to-protamine transition during spermiogenesis
J Bao, MT Bedford - Reproduction (Cambridge, England), 2016 - ncbi.nlm.nih.gov
In mammals, male germ cells differentiate from haploid round spermatids to flagella-
containing motile sperm, in a process called spermiogenesis. This process is distinct from …
containing motile sperm, in a process called spermiogenesis. This process is distinct from …
CARM1/PRMT4: making its mark beyond its function as a transcriptional coactivator
Coactivator-associated arginine methyltransferase 1 (CARM1), identified 20 years ago as a
coregulator of transcription, is an enzyme that catalyzes arginine methylation of proteins …
coregulator of transcription, is an enzyme that catalyzes arginine methylation of proteins …
Insights into the sperm chromatin and implications for male infertility from a protein perspective
Male germ cells undergo an extreme but fascinating process of chromatin remodeling that
begins in the testis during the last phase of spermatogenesis and continues through …
begins in the testis during the last phase of spermatogenesis and continues through …
A bromodomain–DNA interaction facilitates acetylation-dependent bivalent nucleosome recognition by the BET protein BRDT
TCR Miller, B Simon, V Rybin, H Grötsch… - Nature …, 2016 - nature.com
Bromodomains are critical components of many chromatin modifying/remodelling proteins
and are emerging therapeutic targets, yet how they interact with nucleosomes, rather than …
and are emerging therapeutic targets, yet how they interact with nucleosomes, rather than …
Paternal epigenetics: mammalian sperm provide much more than DNA at fertilization
The spermatozoon is a highly differentiated cell with unique characteristics: it is mobile,
thanks to its flagellum, and is very compact. The sperm cytoplasm is extremely reduced …
thanks to its flagellum, and is very compact. The sperm cytoplasm is extremely reduced …
The interplay between replacement and retention of histones in the sperm genome
U Torres-Flores, A Hernández-Hernández - Frontiers in genetics, 2020 - frontiersin.org
The genome of eukaryotes is highly organized within the cell nucleus, this organization per
se elicits gene regulation and favors other mechanisms like cell memory throughout …
se elicits gene regulation and favors other mechanisms like cell memory throughout …
Proteomics of post-translational modifications of mammalian spermatozoa
MA Baker - Cell and tissue research, 2016 - Springer
It is hard to fathom that one of the most highly differentiated cells in the body, the
spermatozoon, spends over half of its developmental life without the capacity for nuclear …
spermatozoon, spends over half of its developmental life without the capacity for nuclear …
The arginine methyltransferase CARM1 represses p300• ACT• CREMτ activity and is required for spermiogenesis
CARM1 is a protein arginine methyltransferase (PRMT) that has been firmly implicated in
transcriptional regulation. However, the molecular mechanisms by which CARM1 …
transcriptional regulation. However, the molecular mechanisms by which CARM1 …
Histone lysine methylation and congenital heart disease: from bench to bedside
X Yi, X Jiang, X Li, DS Jiang - … Journal of Molecular …, 2017 - spandidos-publications.com
Histone post-translational modifications (PTM) as one of the key epigenetic regulatory
mechanisms that plays critical role in various biological processes, including regulating …
mechanisms that plays critical role in various biological processes, including regulating …
Spermatid-specific linker histone HILS1 is a poor condenser of DNA and chromatin and preferentially associates with LINE-1 elements
Background Linker histones establish and maintain higher-order chromatin structure. Eleven
linker histone subtypes have been reported in mammals. HILS1 is a spermatid-specific …
linker histone subtypes have been reported in mammals. HILS1 is a spermatid-specific …