Early evaluation of treatment response and prediction of disease evolution are key issues in
the management of people with multiple sclerosis (MS). In the past 20 years, MRI has …

A critical role for IL-17, a cytokine produced by T helper 17 (Th17) cells, has been indicated
in the pathogenesis of chronic inflammatory and autoimmune diseases. A positive effect of …

Multiple sclerosis (MS) is an inflammatory-mediated demyelinating disease of the human
central nervous system. The clinical disease course is variable, usually starts with reversible …

Quantitative measurement of brain size, shape, and temporal change (for example, in order
to estimate atrophy) is increasingly important in biomedical image analysis applications …

Multiple Sclerosis (MS) is an inflammatory demyelinating disease of the central nervous
system that causes motor, sensory, and cognitive deficits. The present study characterized …

Multiple sclerosis (MS) is a chronic disease with an inflammatory and neurodegenerative
pathology. Axonal loss and neurodegeneration occurs early in the disease course and may …

Imaging studies of cerebral volumes often adjust for factors such as age that may confound
between-subject comparisons. However the use of nuisance covariates in imaging studies is …

Prognosis of multiple sclerosis is highly variable. Clinical variables have been identified that
are assessable early in the disease and are predictors of the time from the disease onset to …

Multiple sclerosis can follow very different patterns of evolution and variable rates of
disability accumulation. This raises the issue whether it represents one or several distinct …

Conventional magnetic resonance images are usually evaluated using the image signal
contrast between tissues and not based on their absolute signal intensities. Quantification of …