The lifespan of an organism is strongly influenced by environmental factors (including diet)
and by internal factors (notably reproductive status). Lipid metabolism is critical for …

Much of the current research on longevity focuses on the aging process within a single
species. Several molecular players (eg IGF1 and MTOR), pharmacological compounds (eg …

Lifespan varies within and across species, but the general principles of its control remain
unclear. Here, we conducted multi-tissue RNA-seq analyses across 41 mammalian species …

In biological systems lipids generate membranes and have a key role in cell signaling and
energy storage. Therefore, there is a wide diversity of molecular lipid expressed at the …

Lipids are essential to brain functions, yet they remain largely unexplored. Here we
investigated the lipidome composition of prefrontal cortex gray matter in 396 cognitively …

Metabolism plays a significant role in the regulation of aging at different levels, and
metabolic reprogramming represents a major driving force in aging. Metabolic …

A lipid profile resistant to oxidative damage is an inherent trait associated with animal
lifespan. However, there is a lack of lipidomic studies on human longevity. Here we use …

Lipids are essential in maintaining brain function, and lipid profiles have been reported to be
altered in aged and Alzheimer's disease (AD) brains as compared to healthy mature brains …

One of the challenges facing science/biology today is uncovering the molecular bases that
support and determine animal and human longevity. Nature, in offering a diversity of animal …

Bats, unique among mammals with powered flight, have many species with the longest size-
proportionate lifespan of all mammals. Evolutionary adaptations would have been required …