The principal source of vitamin D in humans is its biosynthesis in the skin through a
chemical reaction dependent on sun exposure. In lesser amounts, the vitamin can be …

The etiology of endemic rickets was discovered a century ago. Vitamin D is the precursor of
25-hydroxyvitamin D and other metabolites, including 1, 25 (OH) 2D, the ligand for the …

1, 25-Dihydroxvitamin D3 [1, 25 (OH) 2D3] is the hormonally active form of vitamin D. The
genomic mechanism of 1, 25 (OH) 2D3 action involves the direct binding of the 1, 25 (OH) …

Deficiency in vitamin D (VitD), a lipid-soluble vitamin and steroid hormone, affects
approximately 24% to 40% of the population of the Western world. In addition to its well …

The routine and often unavoidable exposure to solar ultraviolet (UV) radiation makes it one
of the most significant environmental DNA-damaging agents to which humans are exposed …

The classical function of Vitamin D, which involves mineral balance and skeletal
maintenance, has been known for many years. With the discovery of vitamin D receptors in …

Vitamin D deficiency is associated with osteoporosis and is thought to increase the risk of
cancer and CVD. Despite these numerous potential health effects, data on vitamin D status …

Background A large number of observational studies have reported harmful effects of low 25-
hydroxyvitamin D (25OHD) levels on non-skeletal outcomes. We performed a systematic …

Introduction: Vitamin D has been primarily studied as an important factor influencing bone
and calcium metabolism. Metabolites of vitamin D are essential for whole-body calcium …

Beyond its critical function in calcium homeostasis, vitamin D has recently been found to
play an important role in the modulation of the immune/inflammation system via regulating …