RNA-binding proteins in human genetic disease

F Gebauer, T Schwarzl, J Valcárcel… - Nature Reviews …, 2021 - nature.com
RNA-binding proteins (RBPs) are critical effectors of gene expression, and as such their
malfunction underlies the origin of many diseases. RBPs can recognize hundreds of …

A brave new world of RNA-binding proteins

MW Hentze, A Castello, T Schwarzl… - Nature reviews Molecular …, 2018 - nature.com
RNA-binding proteins (RBPs) are typically thought of as proteins that bind RNA through one
or multiple globular RNA-binding domains (RBDs) and change the fate or function of the …

Comprehensive identification of RNA-binding domains in human cells

A Castello, B Fischer, CK Frese, R Horos, AM Alleaume… - Molecular cell, 2016 - cell.com
Mammalian cells harbor more than a thousand RNA-binding proteins (RBPs), with half of
these employing unknown modes of RNA binding. We developed RBDmap to determine the …

Context-dependent control of alternative splicing by RNA-binding proteins

XD Fu, M Ares Jr - Nature Reviews Genetics, 2014 - nature.com
Sequence-specific RNA-binding proteins (RBPs) bind to pre-mRNA to control alternative
splicing, but it is not yet possible to read the'splicing code'that dictates splicing regulation on …

[HTML][HTML] Insights into RNA biology from an atlas of mammalian mRNA-binding proteins

A Castello, B Fischer, K Eichelbaum, R Horos… - Cell, 2012 - cell.com
RNA-binding proteins (RBPs) determine RNA fate from synthesis to decay. Employing two
complementary protocols for covalent UV crosslinking of RBPs to RNA, we describe a …

Advances and challenges in the detection of transcriptome‐wide protein–RNA interactions

EC Wheeler, EL Van Nostrand… - Wiley Interdisciplinary …, 2018 - Wiley Online Library
RNA binding proteins (RBPs) play key roles in determining cellular behavior by
manipulating the processing of target RNAs. Robust methods are required to detect the …

Phosphorylation of serine 10 in histone H3, what for?

C Prigent, S Dimitrov - Journal of cell science, 2003 - journals.biologists.com
Eukaryotic cells must possess mechanisms for condensing and decondensing chromatin.
Chromatin condensation is particularly evident during mitosis and cell death induced by …

In planta determination of the mRNA-binding proteome of Arabidopsis etiolated seedlings

M Reichel, Y Liao, M Rettel, C Ragan, M Evers… - The Plant …, 2016 - academic.oup.com
RNA binding proteins (RBPs) control the fate and expression of a transcriptome. Despite this
fundamental importance, our understanding of plant RBPs is rudimentary, being mainly …

DNA–protein crosslink proteases in genome stability

A Ruggiano, K Ramadan - Communications Biology, 2021 - nature.com
Proteins covalently attached to DNA, also known as DNA–protein crosslinks (DPCs), are
common and bulky DNA lesions that interfere with DNA replication, repair, transcription and …

System-wide identification of RNA-binding proteins by interactome capture

A Castello, R Horos, C Strein, B Fischer… - Nature protocols, 2013 - nature.com
Owing to their preeminent biological functions, the repertoire of expressed RNA-binding
proteins (RBPs) and their activity states are highly informative about cellular systems. We …