The aim of this article is to describe the current and potential clinical translation of
pharmacological inhibitors of poly (ADP-ribose) polymerase (PARP) for the therapy of …

Poly (ADP-ribosyl) ation is an immediate cellular repair response to DNA damage and is
catalyzed primarily by poly (ADP-ribose) polymerase-1 (PARP1), which is the most …

Throughout the last 2 decades, experimental evidence from in vitro studies and preclinical
models of disease has demonstrated that reactive oxygen and nitrogen species, including …

Accumulating evidence suggests that the reactive oxygen and nitrogen species are
generated in cardiomyocytes and endothelial cells during myocardial ischemia/reperfusion …

Atrial fibrillation (AF) is the most common clinical tachyarrhythmia with a strong tendency to
progress in time. AF progression is driven by derailment of protein homeostasis, which …

Poly (ADP-ribosyl) ation, attaching the ADP-ribose polymer chain to the receptor protein, is a
unique posttranslational modification. Poly (ADP-ribose) polymerase-1 (PARP-1) is a well …

Poly (ADP-ribose) polymerases (PARPs) are defined as cell signaling enzymes that catalyze
the transfer of ADP-ribose units from NAD+ to a number of acceptor proteins. PARP-1, the …

Macrovascular and microvascular diseases are currently the principal causes of morbidity
and mortality in subjects with diabetes. Disorders of the physiological signaling functions of …

Here we overview the role of reactive nitrogen species (nitrosative stress) and associated
pathways in the pathogenesis of diabetic vascular complications. Increased extracellular …

Autophagy is a key regulatory process in maintaining cellular homoeostasis via lysosome
degradation. Growing evidence reveals that poly (ADP-ribose) polymerase-1 (PARP1) is …