The Earth turns on its axis every 24 h; almost all life on the planet has a mechanism—
circadian rhythmicity—to anticipate the daily changes caused by this rotation. The molecular …

Background: The circadian timing system or circadian clock plays a crucial role in many
biological processes, such as the sleep-wake cycle, hormone secretion, cardiovascular …

The blood–brain barrier (BBB) is an evolutionarily conserved, structural, and functional
separation between circulating blood and the central nervous system (CNS). By controlling …

Cardiac arrhythmias are a leading cause of cardiovascular death. It has long been accepted
that life-threatening cardiac arrhythmias (ventricular tachycardia, ventricular fibrillation, and …

Circadian clocks maintain periodicity in internal cycles of behavior, physiology, and
metabolism, enabling organisms to anticipate the 24-h rotation of the Earth. In mammals …

The diurnal variation in the incidence of myocardial infarction and stroke may reflect an
influence of the molecular clock and/or the time dependence of exposure to environmental …

Circadian misalignment has been implicated in the development of obesity, diabetes
mellitus, and cardiovascular disease. Time-of-day–dependent synchronization of organisms …

Background—Cardiovascular disease is the leading cause of death for both men and
women in the United States and the world. A profound pattern exists in the time of day at …

Cardiac function and dysfunction exhibit striking time-of-day-dependent oscillations.
Disturbances in both daily rhythms and sleep are associated with increased risk of heart …

The circadian clock regulates many aspects of physiology, including cardiovascular function.
Internal oscillators exist in endothelial, smooth muscle cells, and fibroblasts of the …