The human CNS follows a pattern of development typical of all mammals, but certain
neurodevelopmental features are highly derived. Building the human CNS requires the …

For a long time, scientists have tried to describe disorders just by genetic or environmental
factors. However, the role of epigenetics in human diseases has been considered from a …

Introduction Several lines of evidence point to a key role for dynamic epigenetic changes
during brain development, maturation, and learning. DNA methylation (mC) is a stable …

Human neurons are functional over an entire lifetime, yet the mechanisms that preserve
function and protect against neurodegeneration during ageing are unknown. Here we show …

Epigenetics is a quickly growing field encompassing mechanisms regulating gene
expression that do not involve changes in the genotype. Epigenetics is of increasing …

Background Several recent studies reported aging effects on DNA methylation levels of
individual CpG dinucleotides. But it is not yet known whether aging-related consensus …

Maternal care influences hypothalamic-pituitary-adrenal (HPA) function in the rat through
epigenetic programming of glucocorticoid receptor expression. In humans, childhood abuse …

The genomes of many animals, plants and fungi are tagged by methylation of DNA cytosine.
To understand the biological significance of this epigenetic mark it is essential to know …

Epigenetic control of gene transcription is critical for normal human development and
cellular differentiation. While alterations of epigenetic marks such as DNA methylation have …

BACKGROUND: Childhood maltreatment and early trauma leave lasting imprints on neural
mechanisms of cognition and emotion. With a rat model of infant maltreatment by a …