Tackling the emerging threat of antifungal resistance to human health

MC Fisher, A Alastruey-Izquierdo, J Berman… - Nature reviews …, 2022 - nature.com
Invasive fungal infections pose an important threat to public health and are an under-
recognized component of antimicrobial resistance, an emerging crisis worldwide. Across a …

[HTML][HTML] Invasive candidiasis

PG Pappas, MS Lionakis, MC Arendrup… - Nature Reviews …, 2018 - nature.com
Invasive candidiasis is an important health-care-associated fungal infection that can be
caused by several Candida spp.; the most common species is Candida albicans, but the …

Twenty Years of the SENTRY Antifungal Surveillance Program: Results for Candida Species From 1997–2016

MA Pfaller, DJ Diekema, JD Turnidge… - Open forum …, 2019 - academic.oup.com
Background The emergence of antifungal resistance threatens effective treatment of
invasive fungal infection (IFI). Invasive candidiasis is the most common health care …

Drug-resistant fungi: an emerging challenge threatening our limited antifungal armamentarium

A Arastehfar, T Gabaldón, R Garcia-Rubio, JD Jenks… - Antibiotics, 2020 - mdpi.com
The high clinical mortality and economic burden posed by invasive fungal infections (IFIs),
along with significant agricultural crop loss caused by various fungal species, has resulted in …

The antifungal pipeline: fosmanogepix, ibrexafungerp, olorofim, opelconazole, and rezafungin

M Hoenigl, R Sprute, M Egger, A Arastehfar… - Drugs, 2021 - Springer
The epidemiology of invasive fungal infections is changing, with new populations at risk and
the emergence of resistance caused by the selective pressure from increased usage of …

[HTML][HTML] European candidaemia is characterised by notable differential epidemiology and susceptibility pattern: Results from the ECMM Candida III study

MC Arendrup, S Arikan-Akdagli, KM Jørgensen… - Journal of Infection, 2023 - Elsevier
The objectives of this study were to assess Candida spp. distribution and antifungal
resistance of candidaemia across Europe. Isolates were collected as part of the third ECMM …

The quiet and underappreciated rise of drug-resistant invasive fungal pathogens

A Arastehfar, C Lass-Flörl, R Garcia-Rubio… - Journal of Fungi, 2020 - mdpi.com
Human fungal pathogens are attributable to a significant economic burden and mortality
worldwide. Antifungal treatments, although limited in number, play a pivotal role in …

Antifungal resistance: a concerning trend for the present and future

JA Hendrickson, C Hu, SL Aitken, N Beyda - Current infectious disease …, 2019 - Springer
Abstract Purpose of Review The global emergence of antifungal resistance among Candida
spp. and Aspergillus spp. is a growing threat to public health, driven largely by the …

A One Health approach to overcoming fungal disease and antifungal resistance

M Woods, JA McAlister… - WIREs Mechanisms of …, 2023 - Wiley Online Library
The global burden of fungal disease poses a substantial threat to human, animal, and
environmental health, endangering both human and livestock populations and creating …

Novel therapeutic approaches to invasive candidiasis: considerations for the clinician

F Lamoth - Infection and Drug Resistance, 2023 - Taylor & Francis
Invasive candidiasis (IC), due to the yeast pathogen Candida, is still a major cause of in-
hospital morbidity and mortality. The limited number of antifungal drug classes and the …