The fibrogenic niche in kidney fibrosis: components and mechanisms

L Li, H Fu, Y Liu - Nature Reviews Nephrology, 2022 - nature.com
Kidney fibrosis, characterized by excessive deposition of extracellular matrix (ECM) that
leads to tissue scarring, is the final common outcome of a wide variety of chronic kidney …

[HTML][HTML] Comorbidity-associated glutamine deficiency is a predisposition to severe COVID-19

T Matsuyama, SK Yoshinaga, K Shibue… - Cell Death & …, 2021 - nature.com
SARS-CoV-2 vaccinations have greatly reduced COVID-19 cases, but we must continue to
develop our understanding of the nature of the disease and its effects on human immunity …

[HTML][HTML] Targeted therapy of kidney disease with nanoparticle drug delivery materials

S Shang, X Li, H Wang, Y Zhou, K Pang, P Li, X Liu… - Bioactive Materials, 2024 - Elsevier
With the development of nanomedicine, nanomaterials have been widely used, offering
specific drug delivery to target sites, minimal side effects, and significant therapeutic effects …

[HTML][HTML] Advanced drug delivery systems for renal disorders

B Alallam, H Choukaife, S Seyam, V Lim, M Alfatama - Gels, 2023 - mdpi.com
Kidney disease management and treatment are currently causing a substantial global
burden. The kidneys are the most important organs in the human urinary system, selectively …

[HTML][HTML] Potential urine proteomic biomarkers for focal segmental glomerulosclerosis and minimal change disease

NV Chebotareva, A Vinogradov… - International Journal of …, 2022 - mdpi.com
Primary focal segmental glomerulosclerosis (FSGS), along with minimal change disease
(MCD), are diseases with primary podocyte damage that are clinically manifested by the …

[HTML][HTML] Densification: Hyaluronan aggregation in different human organs

A Stecco, M Cowman, N Pirri, P Raghavan, C Pirri - Bioengineering, 2022 - mdpi.com
Hyaluronan (HA) has complex biological roles that have catalyzed clinical interest in several
fields of medicine. In this narrative review, we provide an overview of HA aggregation, also …

[HTML][HTML] The role of hyaluronan in renal cell carcinoma

C Jin, Y Zong - Frontiers in Immunology, 2023 - frontiersin.org
Renal cell carcinoma (RCC) is associated with high mortality rates worldwide and survival
among RCC patients has not improved significantly in the past few years. A better …

Genome‐scale metabolic modelling of SARS‐CoV‐2 in cancer cells reveals an increased shift to glycolytic energy production

E Yaneske, G Zampieri, L Bertoldi, G Benvenuto… - FEBS …, 2021 - Wiley Online Library
Cancer is considered a high‐risk condition for severe illness resulting from COVID‐19. The
interaction between severe acute respiratory syndrome coronavirus‐2 (SARS‐CoV‐2) and …

Hydrogel and nanoparticle carriers for kidney disease therapy: trends and recent advancements

X Gu, Z Liu, Y Tai, L Zhou, K Liu, D Kong… - Progress in …, 2022 - iopscience.iop.org
Achieving local therapeutic agent concentration in the kidneys through traditional systemic
administration routes have associated concerns with off-target drug effects and toxicity …

[HTML][HTML] 4-Methylumbeliferone treatment at a dose of 1.2 g/kg/day is safe for long-term usage in rats

K Štěpánková, D Mareková, K Kubášová… - International Journal of …, 2023 - mdpi.com
4-methylumbelliferone (4MU) has been suggested as a potential therapeutic agent for a
wide range of neurological diseases. The current study aimed to evaluate the physiological …