As the process that silences gene expression ensues during development, the stage is set
for the activity of Polycomb-repressive complex 2 (PRC2) to maintain these repressed gene …

Ciliated protozoa undergo large-scale developmental rearrangement of their somatic
genomes when forming a new transcriptionally active macronucleus during conjugation …

RNA interference (RNAi), a cellular process through which small RNAs target and regulate
complementary RNA transcripts, has well-characterized roles in post-transcriptional gene …

It is generally considered that Polycomb Repressive Complex (PRC) 2 deposits the histone
mark H3K27me3 on silent protein-coding genes, while transposable elements are …

In animal germlines, transposons are silenced at the transcriptional or post-transcriptional
level to prevent deleterious expression. Ciliates employ a more direct approach by …

In animals and plants, the H3K9me3 and H3K27me3 chromatin silencing marks are
deposited by different protein machineries. H3K9me3 is catalyzed by the SET-domain SU …

Ciliates are a highly divergent group of unicellular eukaryotes with separate somatic and
germline genomes found in distinct dimorphic nuclei. This characteristic feature is tightly …

Summary Polycomb repressive complex 2 (PRC2) maintains transcriptionally silent genes in
a repressed state via deposition of histone H3K27-trimethyl (me3) marks. PRC2 has also …

During their development following sexual conjugation, ciliates excise numerous internal
eliminated sequences (IESs) from a copy of the germline genome to produce the functional …

Ciliates are unicellular eukaryotes with both a germline genome and a somatic genome in
the same cytoplasm. The somatic macronucleus (MAC), responsible for gene expression, is …