[HTML][HTML] Gut microbiota modulation of efficacy and toxicity of cancer chemotherapy and immunotherapy

D Chrysostomou, LA Roberts, JR Marchesi, JM Kinross - Gastroenterology, 2023 - Elsevier
Accumulating evidence supports not only the functional role of the gut microbiome in cancer
development and progression but also its role in defining the efficacy and toxicity of …

Antidepressive mechanisms of probiotics and their therapeutic potential

SJ Yong, T Tong, J Chew, WL Lim - Frontiers in neuroscience, 2020 - frontiersin.org
The accumulating knowledge of the host-microbiota interplay gives rise to the microbiota-gut-
brain (MGB) axis. The MGB axis depicts the interkingdom communication between the gut …

Decorating bacteria with a therapeutic nanocoating for synergistically enhanced biotherapy

W Hou, J Li, Z Cao, S Lin, C Pan, Y Pang, J Liu - Small, 2021 - Wiley Online Library
Disorders in the gut microbiota have been implicated in various diseases, such as
inflammatory bowel diseases, diabetes, and cancers. Oral microecologics are of great …

The ameliorative role of probiotics in 5-fluorouracil induced intestinal mucositis

AAXH Sim, JY Cheam, JWF Law… - … in Microbes and …, 2023 - research.monash.edu
Colorectal cancer (CRC) remains one of the top cancers in the world. Although early
detection improves the survival rate to around 90%, late detection would mean the need to …

The airway microbiome at birth

CV Lal, C Travers, ZH Aghai, P Eipers, T Jilling… - Scientific reports, 2016 - nature.com
Alterations of pulmonary microbiome have been recognized in multiple respiratory
disorders. It is critically important to ascertain if an airway microbiome exists at birth and if so …

Lactobacillus casei Variety rhamnosus Probiotic Preventively Attenuates 5-Fluorouracil/Oxaliplatin-Induced Intestinal Injury in a Syngeneic Colorectal Cancer Model

CW Chang, CY Liu, HC Lee, YH Huang, LH Li… - Frontiers in …, 2018 - frontiersin.org
Adjuvant 5-fluorouracil (5-FU)-based chemotherapy, including FOLFOX (5-FU, leucovorin,
and oxaliplatin), is recommended for colorectal cancer. However, intestinal mucositis …

Probiotics, prebiotics, synbiotics, and paraprobiotics as a therapeutic alternative for intestinal mucositis

VL Batista, TF Da Silva, LCL de Jesus… - Frontiers in …, 2020 - frontiersin.org
Intestinal mucositis, a cytotoxic side effect of the antineoplastic drug 5-fluorouracil (5-FU), is
characterized by ulceration, inflammation, diarrhea, and intense abdominal pain, making it …

Apoptosis, dysbiosis and expression of inflammatory cytokines are sequential events in the development of 5‐fluorouracil‐induced intestinal mucositis in mice

N Hamouda, T Sano, Y Oikawa, T Ozaki… - Basic & clinical …, 2017 - Wiley Online Library
Abstract The chemotherapeutic agent 5‐fluorouracil (5‐FU) causes intestinal mucositis with
severe diarrhoea, but the pathogenesis is not fully understood. In this study, we investigated …

Unlocking the potential of probiotics: a comprehensive review on research, production, and regulation of probiotics

TF da Silva, RA Glória, MF Americo, AS Freitas… - Probiotics and …, 2024 - Springer
This review provides a comprehensive overview of the current state of probiotic research,
covering a wide range of topics, including strain identification, functional characterization …

Experimental chemotherapy-induced mucositis: a scoping review guiding the design of suitable preclinical models

J Huang, AYM Hwang, Y Jia, B Kim, M Iskandar… - International Journal of …, 2022 - mdpi.com
Mucositis is a common and most debilitating complication associated with the cytotoxicity of
chemotherapy. The condition affects the entire alimentary canal from the mouth to the anus …