Thyroglobulin (Tg) is a vertebrate secretory protein synthesized in the thyrocyte endoplasmic
reticulum (ER), where it acquires N-linked glycosylation and conformational maturation …

Congenital hypothyroidism (CH) is a state of insufficient thyroid hormone supply to the
organism, starting in utero. Two forms of permanent primary or thyroidal CH are known …

Iodide Handling Disorders lead to defects of the biosynthesis of thyroid hormones (thyroid
dyshormonogenesis, TD) and thereafter congenital hypothyroidism (CH), the most common …

Thyroglobulin (TG) plays a main role in the biosynthesis of thyroid hormones (TH), and, thus,
it is involved in a wide range of vital functions throughout the life cycle of all vertebrates …

Thyroid disorders in infancy, childhood and adolescence represent common and usually
treatable endocrine disorders. Thyroid hormones are essential for normal development and …

Alzheimer's disease (AD) is an acquired disorder of cognitive and behavioral impairment. It
is considered to be caused by variety of factors, such as age, environment and genetic …

Thyroid dyshormonogenesis due to thyroglobulin (TG) gene mutations have an estimated
incidence of approximately 1 in 100,000 newborns. The clinical spectrum ranges from …

Mutations in Thyroglobulin (TG) are common genetic causes of congenital hypothyroidism
(CH). But the TG mutation spectrum and its frequency in Chinese CH patients have not been …

Thyroglobulin (TG) is a large glycosylated protein of 2767 amino acids, secreted by the
thyrocytes into the follicular lumen. It plays an essential role in the process of thyroid …

Thyroglobulin (TG) is a homodimeric glycoprotein synthesized by the thyroid gland. To date,
two hundred twenty-seven variations of the TG gene have been identified in humans …