Molecular insights into Crimean-Congo hemorrhagic fever virus
Crimean-Congo hemorrhagic fever virus (CCHFV) is a tick-borne pathogen that causes high
morbidity and mortality. Efficacy of vaccines and antivirals to treat human CCHFV infections …
morbidity and mortality. Efficacy of vaccines and antivirals to treat human CCHFV infections …
Neglected filoviruses
R Burk, L Bollinger, JC Johnson, J Wada… - FEMS microbiology …, 2016 - academic.oup.com
Eight viruses are currently assigned to the family Filoviridae. Marburg virus, Sudan virus
and, in particular, Ebola virus have received the most attention both by researchers and the …
and, in particular, Ebola virus have received the most attention both by researchers and the …
[HTML][HTML] Systematic analysis of monoclonal antibodies against Ebola virus GP defines features that contribute to protection
Antibodies are promising post-exposure therapies against emerging viruses, but which
antibody features and in vitro assays best forecast protection are unclear. Our international …
antibody features and in vitro assays best forecast protection are unclear. Our international …
[HTML][HTML] Longitudinal analysis of the human B cell response to Ebola virus infection
Ebola virus (EBOV) remains a public health threat. We performed a longitudinal study of B
cell responses to EBOV in four survivors of the 2014 West African outbreak. Infection …
cell responses to EBOV in four survivors of the 2014 West African outbreak. Infection …
Cross-reactive and potent neutralizing antibody responses in human survivors of natural ebolavirus infection
Recent studies have suggested that antibody-mediated protection against the Ebolaviruses
may be achievable, but little is known about whether or not antibodies can confer cross …
may be achievable, but little is known about whether or not antibodies can confer cross …
Non-neutralizing antibodies from a Marburg infection survivor mediate protection by Fc-effector functions and by enhancing efficacy of other antibodies
Marburg virus (MARV) and Ebola virus (EBOV) belong to the family Filoviridae. MARV
causes severe disease in humans with high fatality. We previously isolated a large panel of …
causes severe disease in humans with high fatality. We previously isolated a large panel of …
The marburgvirus-neutralizing human monoclonal antibody MR191 targets a conserved site to block virus receptor binding
Since their first identification 50 years ago, marburgviruses have emerged several times,
with 83%–90% lethality in the largest outbreaks. Although no vaccines or therapeutics are …
with 83%–90% lethality in the largest outbreaks. Although no vaccines or therapeutics are …
A roadmap for the molecular farming of viral glycoprotein vaccines: engineering glycosylation and glycosylation-directed folding
Immunization with recombinant glycoprotein-based vaccines is a promising approach to
induce protective immunity against viruses. However, the complex biosynthetic maturation …
induce protective immunity against viruses. However, the complex biosynthetic maturation …
Post-exposure immunotherapy for two ebolaviruses and Marburg virus in nonhuman primates
JM Brannan, S He, KA Howell, LI Prugar, W Zhu… - Nature …, 2019 - nature.com
Abstract The 2013–2016 Ebola virus (EBOV) disease epidemic demonstrated the grave
consequences of filovirus epidemics in the absence of effective therapeutics. Besides EBOV …
consequences of filovirus epidemics in the absence of effective therapeutics. Besides EBOV …
Single-component multilayered self-assembling nanoparticles presenting rationally designed glycoprotein trimers as Ebola virus vaccines
L He, A Chaudhary, X Lin, C Sou, T Alkutkar… - Nature …, 2021 - nature.com
Ebola virus (EBOV) glycoprotein (GP) can be recognized by neutralizing antibodies (NAbs)
and is the main target for vaccine design. Here, we first investigate the contribution of the …
and is the main target for vaccine design. Here, we first investigate the contribution of the …