Healthy aging and human longevity are intricate phenotypes affected by environmental
factors such as physical exercise, diet, health habits, and psychosocial situations as well as …

Aging is a natural phenomenon that occurs in all living organisms. In humans, aging is
associated with lowered overall functioning and increased mortality out of the risk for various …

L-lactate was long considered a glycolytic by-product but is now being recognized as a
signaling molecule involved in cell survival. In this manuscript, we report the role of L-lactate …

Genetic and pharmacological interventions have successfully extended healthspan and
lifespan in animals, but their genetic interventions are not appropriate options for human …

Here, we review three sets of key proteins and their corresponding downstream pathways
that have been linked to extending lifespan and promoting health span in a wide range of …

The insulin like growth factor (IGF) axis plays a fundamental role in normal growth and
development, and when deregulated makes an important contribution to disease. Here, we …

Caenorhabditis elegans is an exceptionally valuable model for aging research because of
many advantages, including its genetic tractability, short lifespan, and clear age‐dependent …

Deregulation of precursor mRNA splicing is associated with many illnesses and has been
linked to age‐related chronic diseases. Here we review recent progress documenting how …

Caenorhabditis elegans is an important model organism with many useful features,
including rapid development and aging, easy cultivation, and genetic tractability. Survival …

Caenorhabditis elegans has been used as a major model organism to identify genetic
factors that regulate organismal aging and longevity. Insulin/insulin-like growth factor 1 (IGF …