Although most antibiotics do not need metal ions for their biological activities, there are a
number of antibiotics that require metal ions to function properly, such as bleomycin (BLM) …

The precise cause of neuronal death in Huntington's disease (HD) is unknown. Although no
single specific protein-protein interaction of mutant huntingtin has emerged as the …

The aureolic acid-type polyketide mithramycin (MTM) has a remarkable cytotoxicity against a
variety of human tumors and has been used for the treatment of several types of cancer …

Chromatin remodeling and transcription regulation are tightly controlled under physiological
conditions. It has been suggested that altered chromatin modulation and transcription …

The promoter of the human dihydrofolate reductase (DHFR) gene contains two consensus
binding sites for the DNA binding protein Sp1. DNAse protection and gel mobility shift …

Enzymes involved in the epigenetic regulation of the genome represent promising starting
points for therapeutic intervention by small molecules, and DNA methyltransferases (DNMT) …

Calcium accumulation in the endoplasmic reticulum is accomplished by sarco/endoplasmic
reticulum calcium transport ATPases (SERCA enzymes). To better characterize the role of …

ABSTRACT Bovine alphaherpesvirus 1 (BoHV-1) infections cause respiratory tract disorders
and suppress immune responses, which can culminate in bacterial pneumonia. Following …

Skeletal muscle function declines in the aging process or disease; however, until now,
skeletal muscle has remained one of the organs most undertreated with medication. In this …

Background Duplications of the chromosome 15q11-q13. 1 region are associated with an
estimated 1 to 3% of all autism cases, making this copy number variation (CNV) one of the …