Mechanisms of HIV-1 neurotropism
R Dunfee, ER Thomas, PR Gorry, J Wang… - Current HIV …, 2006 - ingentaconnect.com
Human immunodeficiency virus type 1 (HIV) infects macrophages and microglia in the CNS
and frequently causes neurocognitive impairment. Although antiviral therapy generally …
and frequently causes neurocognitive impairment. Although antiviral therapy generally …
Structure of an unliganded simian immunodeficiency virus gp120 core
B Chen, EM Vogan, H Gong, JJ Skehel, DC Wiley… - Nature, 2005 - nature.com
Envelope glycoproteins of human and simian immunodeficiency virus (HIV and SIV)
undergo a series of conformational changes when they interact with receptor (CD4) and co …
undergo a series of conformational changes when they interact with receptor (CD4) and co …
Molecular architectures of trimeric SIV and HIV-1 envelope glycoproteins on intact viruses: strain-dependent variation in quaternary structure
The initial step in target cell infection by human, and the closely related simian
immunodeficiency viruses (HIV and SIV, respectively) occurs with the binding of trimeric …
immunodeficiency viruses (HIV and SIV, respectively) occurs with the binding of trimeric …
Phenotypic and immunologic comparison of clade B transmitted/founder and chronic HIV-1 envelope glycoproteins
CB Wilen, NF Parrish, JM Pfaff, JM Decker… - Journal of …, 2011 - Am Soc Microbiol
Sexual transmission of human immunodeficiency virus type 1 (HIV-1) across mucosal
barriers is responsible for the vast majority of new infections. This relatively inefficient …
barriers is responsible for the vast majority of new infections. This relatively inefficient …
A quantitative affinity-profiling system that reveals distinct CD4/CCR5 usage patterns among human immunodeficiency virus type 1 and simian immunodeficiency virus …
SH Johnston, MA Lobritz, S Nguyen, K Lassen… - Journal of …, 2009 - Am Soc Microbiol
The affinity of human immunodeficiency virus (HIV) envelope for CD4 and CCR5 appears to
be associated with aspects of R5 virus (virus using the CCR5 coreceptor) pathogenicity …
be associated with aspects of R5 virus (virus using the CCR5 coreceptor) pathogenicity …
The SIV envelope glycoprotein, viral tropism, and pathogenesis: novel insights from nonhuman primate models of AIDS
AE Swanstrom, GQ Del Prete, C Deleage… - Current HIV …, 2018 - ingentaconnect.com
Background: Cellular tropism of human immunodeficiency virus (HIV-1) is closely linked to
interactions between the viral envelope glycoprotein (Env) with CD4 and chemokine …
interactions between the viral envelope glycoprotein (Env) with CD4 and chemokine …
Lineage-specific differences between human and simian immunodeficiency virus regulation of gp120 trimer association and CD4 binding
Metastable conformations of the gp120 and gp41 envelope glycoproteins of human
immunodeficiency virus type 1 (HIV-1) and simian immunodeficiency virus (SIV) must be …
immunodeficiency virus type 1 (HIV-1) and simian immunodeficiency virus (SIV) must be …
Characterization and implementation of a diverse simian immunodeficiency virus SIVsm envelope panel in the assessment of neutralizing antibody breadth elicited in …
KM Kilgore, MK Murphy, SL Burton, KS Wetzel… - Journal of …, 2015 - Am Soc Microbiol
Antibodies that can neutralize diverse viral strains are likely to be an important component of
a protective human immunodeficiency virus type 1 (HIV-1) vaccine. To this end, preclinical …
a protective human immunodeficiency virus type 1 (HIV-1) vaccine. To this end, preclinical …
[HTML][HTML] Relationship of HIV-1 and SIV envelope glycoprotein trimer occupation and neutralization
Insights into the process of HIV-1 neutralization may assist rational vaccine design. Here, we
compared antibody neutralization against the JR-FL primary isolate and trimer binding …
compared antibody neutralization against the JR-FL primary isolate and trimer binding …
Loss of a conserved N-linked glycosylation site in the simian immunodeficiency virus envelope glycoprotein V2 region enhances macrophage tropism by increasing …
Human immunodeficiency virus (HIV) and simian immunodeficiency virus (SIV) strains differ
in their capacity to replicate in macrophages, but mechanisms underlying these differences …
in their capacity to replicate in macrophages, but mechanisms underlying these differences …