Introduction 3. Cellular plasminogen regulation 3.1. Structure and function of plasminogen
3.2. Activation of plasminogen 4. Observations from model systems that define the role of …

Migration of cancer cells is one of the key factors responsible for cancer metastasis. The
elucidation of mechanisms responsible for the highly invasive potential of cancer cells can …

Malignant tumors have a capacity to degrade the extracellular matrix (ECM) by controlled
proteolysis. One proteolytic system involved in these processes is the urokinase-type …

Two upstream regions of the human urokinase (uPA) gene regulate its transcription: the
minimal promoter (MP) and the enhancer element. The activity of the minimal promoter is …

Les sentiers signalétiques impliquant les protéine-kinases activées par les mitogènes
(MAPK) sont activés par toute une pléthore de stimulus. La littérature fourmille d'articles …

The earthworm, which has stasis removal and wound‐healing functions, is a widely used
Chinese herbal medicine in China. Schwann cell migration is critical for the regeneration of …

Mammary tumor cells are required to degrade the surrounding matrix and disseminate in
order to metastasize, and both of these processes are controlled by a tumor cell-signaling …

In vivo, tissues and organs are exposed to numerous stressors that require cells to respond
appropriately for viability and homeostasis. Cells respond to these stressors, which range …

Protein kinases, particularly mitogen-activated protein kinases and receptor-tyrosine kinases
play crucial roles in mammalian cellular metabolism by regulating intracellular signaling …

Background: Regulation of the extracellular matrix turnover is a crucial process in wound
healing and the progress of periodontal disease. It has been proposed that urokinase‐type …