PI3K/AKT/mTOR signaling transduction pathway and targeted therapies in cancer

A Glaviano, ASC Foo, HY Lam, KCH Yap, W Jacot… - Molecular cancer, 2023 - Springer
Abstract The PI3K/AKT/mTOR (PAM) signaling pathway is a highly conserved signal
transduction network in eukaryotic cells that promotes cell survival, cell growth, and cell …

Role of mTOR inhibitors in epilepsy treatment

K Sadowski, K Kotulska-Jóźwiak, S Jóźwiak - Pharmacological Reports, 2015 - Elsevier
In spite of the fact, that subsequent new antiepileptic drugs (AEDs) are being introduced into
clinical practice, the percentage of drug-resistant epilepsy cases remains stable. Although a …

Wnt‐5a signaling is correlated with infiltrative activity in human glioma by inducing cellular migration and MMP‐2

M Kamino, M Kishida, T Kibe, K Ikoma, M Iijima… - Cancer …, 2011 - Wiley Online Library
Wnts are secreted ligands that consist of 19 members in humans, regulate cell proliferation,
differentiation, motility and fate in many stages including the embryonic stage and …

Activation of Wnt/β-catenin/Tcf signaling pathway in human astrocytomas

GR Sareddy, M Panigrahi, S Challa… - Neurochemistry …, 2009 - Elsevier
Astrocytomas are the most common form of primary brain tumors. Understanding the
molecular basis of development and progression of astrocytomas is required to develop …

Merlin is a potent inhibitor of glioma growth

YKI Lau, LB Murray, SS Houshmandi, Y Xu… - Cancer research, 2008 - AACR
Abstract Neurofibromatosis 2 (NF2) is an inherited cancer syndrome in which affected
individuals develop nervous system tumors, including schwannomas, meningiomas, and …

Vascular injury during elevated glucose can be mitigated by erythropoietin and Wnt signaling

ZZ Chong, YC Shang, K Maiese - Current neurovascular …, 2007 - ingentaconnect.com
Impacting a significant portion of the world's population with increasing incidence in
minorities, the young, and the physically active, diabetes mellitus (DM) and its complications …

Wnt1 Neuroprotection Translates into Improved Neurological Function during Oxidant Stress and Cerebral Ischemia Through AKT1 and Mitochondrial Apoptotic …

ZZ Chong, YC Shang, J Hou… - Oxidative medicine and …, 2010 - Wiley Online Library
Although essential for the development of the nervous system, Wnt1 also has been
associated with neurodegenerative disease and cognitive loss during periods of oxidative …

Novel avenues of drug discovery and biomarkers for diabetes mellitus

K Maiese, ZZ Chong, YC Shang… - The Journal of Clinical …, 2011 - Wiley Online Library
Globally, developed nations spend a significant amount of their resources on health care
initiatives that poorly translate into increased population life expectancy. As an example, the …

Morphologic, immunohistochemical, and genetic differences between high-grade and low-grade fetal adenocarcinomas of the lung

Y Li, S Xi, J Yong, X Wu, X Yang… - The American Journal of …, 2021 - journals.lww.com
Fetal adenocarcinoma of the lung (FLAC) is a rare lung tumor classified into low-grade fetal
adenocarcinoma of the lung (LG-FLAC) and high-grade fetal adenocarcinoma of the lung …

Obesity and hyperglycemia lead to impaired post‐ischemic recovery after permanent ischemia in mice

J Tulsulkar, SE Nada, BD Slotterbeck, MF McInerney… - …, 2016 - Wiley Online Library
Objective Obesity‐induced diabetes has increased over the years and has become one of
the risk factors for stroke. We investigated the influence of diet‐induced obesity and …