The elucidation of the function of the PINK1 protein kinase and Parkin ubiquitin E3 ligase in
the elimination of damaged mitochondria by autophagy (mitophagy) has provided …

Parkinson's disease (PD) is the second most common neurodegenerative disease and
represents a looming public health crisis as the global population ages. While the etiology of …

Activating mutations in the leucine-rich repeat kinase 2 (LRRK2) cause Parkinson's disease,
and previously we showed that activated LRRK2 phosphorylates a subset of Rab GTPases …

Mutations that activate LRRK2 protein kinase cause Parkinson's disease. LRRK2
phosphorylates a subset of Rab GTPases within their Switch-II motif controlling interaction …

Parkinson's disease (PD) is known as a mitochondrial disease. Some even regarded it
specifically as a disorder of the complex I of the electron transport chain (ETC). The ETC is …

Parkinson's disease (PD) is a progressive neurodegenerative disorder, for which no disease‐
modifying therapies are available to date. Although understanding of the precise aetiology of …

Parkinson's disease (PD) is a leading cause of neurodegeneration that is defined by the
selective loss of dopaminergic neurons and the accumulation of protein aggregates called …

Rab8a is associated with the dynamic regulation of membrane protrusions in polarized cells.
Rab8a is one of several Rab GTPases that are substrates of leucine-rich repeat kinase 2 …

Loss-of-function mutations in PTEN-induced kinase 1 (PINK1) are a frequent cause of early-
onset Parkinson's disease (PD). Stabilization of PINK1 at the translocase of outer membrane …

The most common mutation in the Leucine-rich repeat kinase 2 gene (LRRK2), G2019S,
causes familial Parkinson's Disease (PD) and renders the encoded protein kinase …